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Ken Lassesen's model
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==Theory== Lasses theorizes that CFS is caused by a shift in gut bacteria. <ref>https://cfsremission.wordpress.com/2015/10/04/latest-model-on-what-cfs-is-and-implication-for-treatment/</ref>. This shift can have many causes including [[stress]], [[virus|viral infection]], [[bacteria|bacterial infection]], and [[vaccine|immunization]]. The shift in gut bacteria also alters host ability to extract and process nutrients, leading to deficiencies in key [[amino acid]]s, [[vitamin]]s, and [[mineral]]s. Variation between patients in the population of gut bacteria explains the heterogeneity of symptoms. ===Gut Bacteria Shifts Seen=== The model is based on the shifts reported in 1998<ref>http://www.ahmf.org/98access/98butt3.html</ref> and 2001<ref>http://www.ahmf.org/01access/01schloeffel.html</ref> at Australian CFS/ME Clinical and Scientific Meeting. He has produced a matrix showing how certain anti-pathogens impacts the 6 key bacteria shifts reported in the literature. {| class="wikitable" |Gut Bacteria |Klebsiella/Enterobacter |Enterococcus |[[Streptococcus]] |[[E. coli|E.Coli]] |[[bifidobacteria|Bifidobacterium]] |[[Lactobacillus]] |Score for CFS |- |Levels in CFS Patients |HIGH |HIGH |HIGH |low |low |low * |- |Tetracyclines |Effective |Resistant |Resistant |Resistant |Resistant |Resistant |1 |- |Macrolides |Effective |Resistant |Resistant |Resistant |Resistant |Resistant |1 |- |Quinolone |Resistant |Effective |Resistant |Resistant |Resistant |Effective |- 1 |- |Metronidazole |Effective |Resistant |Resistant |Effective |Resistant |Resistant |- 1 |- |Amoxycillin |Resistant |Effective |Effective |Resistant |Effective |Effective |- 2 |- |Silver |Resistant |Effective |Effective |Resistant |Effective |Effective |- 2 |- |[[probiotic|Lactobacillus probiotics]] |Resistant |Resistant |Effective |Effective |Effective | n/a |- 3 |} Scoring done by 1 for each EFFECTIVE in high (good) and -2 for each EFFECTIVE in low (the harm is more significant than the good). Postive scores are desired<ref>https://cfsremission.wordpress.com/2013/12/26/why-jadins-antibiotics-protocol-usually-work-pasteur-institute-got-the-solution-right-and-the-explanation-wrong/</ref> ===Hypercoagulation=== Lassesen also emphasizes [[hypercoagulation]] as a major factor in CFS, which in his case is at least in part genetic.<ref>https://cfsremission.wordpress.com/2015/12/08/restore-for-gut-health-danger-will-robinson/</ref>
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