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Thyroid hormone
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==Types of thyroid hormones== ===Thyroxine (T4) (90%)=== [[Thyroxine]] (abbreviated as [[T4]]) accounts for 90% of the hormone produced by the [[thyroid gland]]. It is physiological inactive and must be converted to T3 in the liver and kidneys. ===Triiodothyronine (T3) (9%)=== [[Triiodothyronine]] (abbreviated as [[T3]]) is the active form of the hormone. Only 9% of the thyroid hormone produced by the thyroid glad is T3. The rest of the physiologically required T3 is converted from T4 within liver and kidney cells by [[deiodinases]], which are [[selenium]]-dependent enzymes. Selenium sufficiency is therefore important for the proper conversion of T4 to T3. Genetic differences can deiodinase production and therefore conversion ability. ===Reverse T3 (rT3) (0.9%) === Reverse T3 is an isomer of T3, that is it has the same chemical formula but a different shape and is physiologically inactive. It is also made from T4 and plays a role in [[euthyroid sick syndrome]], where rT3 levels are elevated in presence of normal T4 and TSH levels. ===Diiodothyronine (T2) === The physiological functions of [[diiodothyronine]] (T2), including [[3,5-diiodo-L-thyronine]], are less well-understood.
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