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Melissa officinalis
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==Evidence== Clinical trials of melissa officinalis (lemon balm) have not been carried out for patients with ME/CFS. Limited clinical trials exist showing effectiveness for many different symptoms, but these are almost all very small trials, on healthy adults, or provide weak evidence due to being unblinded studies, lack of a control group, or other methodology flaws.<ref name="Swiader2019" /> Some evidence has been found for lemon balm showing: * antioxidant effects * reduced [[anxiety]] in the short-term and increased sense of calm * reduced [[heart palpitation]]s in the short-term * reduced [[premenstrual syndrome]] symptoms * reduced [[Sleep dysfunction|insomnia]] including in a pilot trial of people with mild to moderate anxiety<ref name="Case2011">{{Cite journal|title=Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances|date=2011|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230760/|journal=Mediterranean Journal of Nutrition and Metabolism|volume=4|issue=3|pages=211–218|last=Cases|first=Julien|last2=Ibarra|first2=Alvin|last3=Feuillère|first3=Nicolas|last4=Roller|first4=Marc|last5=Sukkar|first5=Samir G.|doi=10.1007/s12349-010-0045-4|pmc=3230760|pmid=22207903|issn=1973-798X}}</ref> * improved [[Sleep dysfunction |sleep quality]] * improved [[concentration problems|concentration]], and * reduced [[cognitive dysfunction]] in mild to moderate Alzheimer's patients<ref name="Swiader2019"/> Świąder et al. (2019) found most trials used a dose of 300mg or 600mg.<ref name="Swiader2019"/>
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Category:Stub pages last edited in 2023
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