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Oxymatrine
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== Oxymatrine in the treatment of ME/CFS == Dr [[John Chia]] found in an informal study that 30% of ME/CFS patients will make major improvements with oxymatrine, and another 20% will make more minor improvements.<ref name="Chia2011Conf">{{citation|last =Chia | first = J | authorlink = Andrew Chia | first2 = A | last2 =Chia | title = Rifampin augments the effects of oxymatrine in patients with myalgic encephalitis/chronic fatigue syndrome|location = International Association for Chronic Fatigue Syndrome/Myalgic Encephalitis (IACFS/ME)-Biennial International Conference|url=http://forums.phoenixrising.me/index.php?threads/i-start-to-relapse-every-time-i-come-off-equilibrant.40479/#post-650624 | date = 2011}}</ref> Dr [[Nancy Klimas]] is also reported to have given oxymatrine to 300 ME/CFS patients with similar success rates.{{Citation needed | date = February 2021}} Dr Chia has formulated his own brand of oxymatrine called [https://equilibranthealth.com/ Equilibrant] (which as well as oxymatrine, also contains other immunomodulatory herbs, but oxymatrine is the primary ingredient). This Chinese herbal supplement can be bought without prescription. In addition, oxymatrine is available as the [https://www.google.com/search?q=White+Tiger+oxymatrine White Tiger oxymatrine] brand (200 mg per tablet) and [http://alternativemedicinesolution.com/oxymatrine/ Alternative Medicine Solutions oxymatrine] (300 mg per capsule), which work with similar efficacy to Equilibrant. As Equilibrant is a proprietary blend, the exact quantity of oxymatrine in each serving of is not known. The Alternative Medicine Solutions oxymatrine [https://alternativemedicinesolution.com/oxymatrine/ website] suggests an oxymatrine dose of 400 to 600 mg daily. Oxymatrine treatment begins by taking half a tablet for the first week or two, then slowly increasing up to 2 or 3 tablets twice daily (so that means 4 or 6 tablets in total daily).<ref name=":0">{{Cite web|url=https://www.youtube.com/watch?v=I44G-tGgLNE&t=4m24s | title = MECFS Alert Episode 39 - Interview with Dr. John Chia, Part 2. See timecode 4:24 | last = | first = | date = |website=MECFS Alert|archive-url=|archive-date=|url-status=|access-date=}}</ref> But the dose should not be escalated if there is significant increase in ME/CFS symptoms. Responders to oxymatrine should see signs of improvement by 4 to 6 weeks, but few may take more than 3 months.<ref name=":1">{{Cite web|url=https://phoenixrising.me/archives/814 | title = Dr. Chia Produces Herbal Immunodulator â Oxymatrine | last = Johnson | first =Cort | date = August 27, 2009 | website = |archive-url=|archive-date=|url-status=|access-date=}}</ref> Once the full benefits of oxymatrine have manifested, Dr Chia says men can stop taking it after 3 to 6 months (though elsewhere he says after 12 months);<ref name=":1" /> however he finds women usually have to continue taking oxymatrine, otherwise they relapse and get worse again.<ref name=":0" /> Dr Chia says [[inosine]] can be taken with oxymatrine in order to augment its effects.<ref name="Chia2011Conf" /> Chia sometimes adds the antibiotic rifampin (also called rifampicin) 300 mg twice daily for 7 days to further boost the action oxymatrine.<ref>{{Cite web|url=http://quixoticmeblog.blogspot.com/2013/03/summary-of-4th-appointment-with-dr-c.html | title = Quixotic ME blog, Summary of 4th appointment with Dr. C | last = Calvin | first = Patrick W. | date = 2013 | website = |archive-url=|archive-date=|url-status=|access-date=}}</ref><ref name="Chia2011Conf" /> Dr Chia suggests that patients with autoimmune tendencies should not take oxymatrine, as there is a risk oxymatrine may trigger rheumatoid arthritis. Autoimmune tendencies means a family history of [[autoimmune disease]]s such as rheumatoid arthritis, [[systemic lupus erythema| lupus]], autoimmune thyroiditis especially [[Graves' disease]], [[multiple sclerosis]], and if the patients have joint pain with positive rheumatoid factor and persistently positive ANA. Dr Chia says patients with known seizure disorders should not take oxymatrine.<ref name="Chia2011Conf" /> Oxymatrine is probably best avoided in young children and during pregnancy.<ref>{{Cite web|url=http://www.itmonline.org/arts/oxyupdate.htm | title = OXYMATRINE: Update on Clinical Effects and Safety. | last=Dharmananda | first = Subhuti | date = 2005 | website = Institute of Traditional Medicine|archive-url=|archive-date=|url-status=|access-date=}}</ref>
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