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Vagus nerve stimulation
(section)
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===Intranasal Mechanical Stimulation=== Intranasal mechanical stimulation of the vagus nerve (e.g., using INMEST) is a non-invasive wearable form of vagus nerve stimulation which has been the subject of a small clinical trial in ME/CFS patients who met the [[Canadian Consensus Criteria]]. INMEST resulted in an significant improvement in symptoms in moderate and severe ME but no improvement in fatigue.<ref name="Rodriguez2020">{{Cite journal | last =Rodriguez | first = Lucie S. T.|author-link = | last2 = Pou | first2 = Christian|author-link2 = | last3 = Lakshmikanth | first3 = Tadepally | author-link3 = | last4 = Zhang | first4 = Jingdian | authorlink4 = | last5 = Mugabo | first5 = Constantin Habimana | authorlink5 = | last6 = Wang | first6 = Jun | authorlink6 = | last7 = Mikes | first7 = Jaromir | last8 = Olin | first8 = Axel | last9 = Chen | first9 = Yang | date = 2020-02-28 | title = Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance|url=https://www.biorxiv.org/content/10.1101/2020.02.20.958249v2|journal=bioRxiv|language=en|volume=|issue=|pages=2020.02.20.958249|doi=10.1101/2020.02.20.958249|pmc=|pmid=|access-date=|quote=|via=}}</ref> {{See also|Intranasal mechanical stimulation}}
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