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===<span id="covid-19">ME/CFS, long COVID, and COVID-19</span>=== '''Queensland researchers find overlap in pathology of long COVID and chronic fatigue syndrome'''<ref>{{Cite news | url=https://www.abc.net.au/news/2022-08-11/long-covid-and-chronic-fatigue-syndrome-pathology-overlap/101318522 | title = Queensland researchers find overlap in pathology of long COVID and chronic fatigue syndrome|publisher=ABC Gold Coast | first = Heidi|last = Sheehan | date = Aug 10, 2022}}</ref> ''ABC Gold Coast'' By: Heidi Sheehan. (Aug 10, 2022) "Researchers say they have found a link in the pathology between [[long COVID]] and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)." "The work is being carried out by professor [[Sonya Marshall-Gradisnik]] and the team at Griffith University's [[National Centre for Neuroimmunology and Emerging Diseases]] (NCNED). "It is the first of its kind in the world to actually biologically identify the overlap in the dysfunction with long COVID and ME/CFS patients," she said. Dr Marshall-Gradisnik said damaged receptors, like a dysfunctional lock and key, do not allow enough [[calcium]] in. "The receptors are located on every cell in the body," she said. These [[ion channel]]s, or the lock and the key that tries to open the door — when we look at ME/CFS patients, that's been significantly impaired. When we looked at the same receptor [in long COVID patients], we're now reporting the same change." The findings will be published in the Journal of Molecular Medicine." '''World first chronic fatigue syndrome findings could fast track response to Long COVID'''<ref>{{Citation | url = https://news.griffith.edu.au/2022/08/11/world-first-chronic-fatigue-syndrome-findings-could-fast-track-response-to-long-covid/ | date = August 11, 2022 | first = Emma|last = O'Connor | title = World first chronic fatigue syndrome findings could fast track response to Long COVID|publisher=Griffith News {{!}} Griffith University}}</ref> ''Griffith News, Griffith University'' By: Emma O'Connor. (August 11, 2022) "Griffith University researchers are hoping to find a treatment for Long COVID after proving the illness shares the same biological impairment as patients with Chronic Fatigue Syndrome (known internationally as Myalgic Encephalomyelitis (ME/CFS)). In a world first, their study suggests COVID-19 could be a potential trigger for ME/CFS and their 10 years of research on ME/CFS could help fast track understanding and treatment of Long Covid. Griffith University's National Centre for Neuroimmunology and Emerging Diseases Director, Professor [[Sonya Marshall-Gradisnik]], said the breakthrough findings will assist with investigations into therapeutic strategies to help both Long COVID and ME/CFS patients." “Patients with Long COVID report neurocognitive, immunological, gastrointestinal, and cardiovascular manifestations, which are also symptoms of ME/CFS,” Professor Marshall-Gradisnik said. "Professor Marshall-Gradisnik and her team have been studying ME/CFS for more than 10 years. In 2020, they adjusted their research to include the impacts of COVID as patients started to experience remarkably similar symptoms. Griffith University's Deputy Vice-Chancellor for Research, Professor Lee Smith, said: "Long COVID is a significant public health issue and we are very proud of the exceptional science being developed here at Griffith and the contribution our NCNED team is making to the health and welfare of potentially millions of patients." The research is funded by a $4 million grant from the Stafford Fox Medical Research Foundation." '''Could this scientist have the answer to long Covid?'''<ref>{{Cite news | url=https://www.thetimes.co.uk/article/b48fe264-72e6-11ec-89e9-22d3d9c31ba2 | date = Jan 12, 2022 | title = Could this scientist have the answer to long Covid|last = Steele | first = Francesca|publisher=The Times|access-date=2022-01-13}}</ref> ''THE TIMES'' By: Francesca Steele. (Jan 12, 2022) "When Whitney Dafoe went from a lively, travel-mad twentysomething to being bedbound with ME/CFS — sometimes just called chronic fatigue syndrome — his father, Ron Davis, was determined to find a cure. Davis, 80, isn’t just a well-meaning amateur, however. He’s a biochemist and director of the Stanford Genome Technology Center, where he helped to develop techniques for gene mapping that were later used in the Human Genome Project. In 2013 a piece in The Atlantic magazine rated him as one of the world’s greatest living inventors alongside Elon Musk and Jeff Bezos. So when he says that it is very important that the discoveries that have since been made by him and others about ME/CFS should not be overlooked when trying to treat those with long Covid, he shouldn’t be taken lightly. “It’s great that people are paying so much attention to long Covid,” he says, “but I think that too much research is starting from the beginning as if this is a new phenomenon. It isn’t.”" "Indeed, there is debate in the scientific community about whether the two illnesses are actually the same thing. Last August The BMJ reported that an inquiry by the House of Lords highlighted the need for patients with suspected long Covid to get a six-month check-up at which their GPs could determine whether they met diagnostic criteria for ME/CFS. In Germany, meanwhile, a small study of 42 patients who presented with moderate to severe fatigue six months after contracting Covid concluded that about half of them met criteria for ME/CFS."<br> '''Have We Been Thinking About Long-Haul Coronavirus All Wrong?'''<ref>{{Cite web|url = https://time.com/5897992/long-haul-coronavirus-me-cfs/ | date = Oct 16, 2020| title = Have We Been Thinking About Long-Haul Coronavirus All Wrong?|last = Ducharme | first = Jamie|website=Time}}</ref> ''Time'' By: Jamie Ducharme. (October 16, 2020) "A few years ago, Jaime Seltzer was helping coordinate research projects, grant applications and funding for a Stanford research group studying a condition called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Up to 2.5 million Americans, including Seltzer, have ME/CFS, and yet it felt like almost no one paid attention to her group’s research. “What is it going to take for researchers to take ME seriously?” she and her colleagues often wondered aloud. The morbid answer, they hypothesized, was a pandemic. Since ME/CFS often follows viral infections, they feared it would take something as destructive as mass illness for the larger scientific community to take notice. Unfortunately, this year they were proven right." '''Coronavirus may cause fatigue syndrome, Fauci says'''<ref>{{Cite web|url = https://edition.cnn.com/world/live-news/coronavirus-pandemic-07-09-20-intl/h_5125152a01f8c98d362cf15d6860ab37 | date = Jul 9, 2020| title = Coronavirus may cause fatigue syndrome, Fauci says | last = Fox | first = Maggie|website=CNN}}</ref> ''CNN'' By: Maggie Fox. (July 9, 2020) There is evidence that some people develop a long-term fatigue syndrome from coronavirus infections, Dr. Anthony Fauci said Thursday. “There may well be a post-viral syndrome associated with Covid-19,” Fauci told a news conference organized by the International AIDS Society. The group is holding a Covid-19 conference as an add-on to its every-other-year AIDS meeting. Fauci said the symptoms resemble those seen in patients with myalgic encephalomyelitis, or ME, once known as chronic fatigue syndrome. '''Coronavirus and heart inflammation in athletes: What we know about myocarditis'''<ref>{{Cite web | title = Coronavirus and heart inflammation in athletes: What we know about myocarditis | first = Marie | last = McCullough | date = August 13, 2020|url=https://www.inquirer.com/health/coronavirus/coronavirus-athletes-cardiac-inflammation-myocarditis-big-10-20200813.html|website=The Inquirer}}</ref> ''The Inquirer'' By: Marie McCullough (August 13, 2020) "A small but growing body of evidence shows that COVID-19 can damage the heart, sometimes fatally, even in a previously healthy young athlete." '''CORONAVIRUS: Infectious diseases expert warns of spike in ME cases'''<ref>{{Cite news | url=https://www.thetimes.co.uk/article/infectious-diseases-expert-warns-of-spike-in-me-cases-307pfbjlg|last = O'Neill|first = Sean | date = 2020-06-24 | website = The Times | title = Infectious diseases expert warns of spike in ME cases}}</ref> ''The Times: Coronavirus'' By: Sean O'Neill. (Jun 24, 2020) "The NHS is facing a “post-viral tsunami” with thousands of people struggling to recover from Covid-19 and experiencing symptoms of the debilitating condition ME, a leading medical researcher said yesterday. Paul Garner, an expert in infectious diseases at the Liverpool School of Tropical Medicine, said he remained exhausted and lacking energy 14 weeks after having had the virus. Professor Garner said he is “unable to be out of bed for more than three hours at a stretch, my arms and legs are permanently fizzing as if injected with Szechuan peppercorns, I have ringing in the ears, intermittent brain fog, palpitations and dramatic mood swings”." '''Could the coronavirus trigger post-viral fatigue syndromes?'''<ref>{{Cite web|url=https://www.newscientist.com/article/mg24632783-400-could-the-coronavirus-trigger-post-viral-fatigue-syndromes/ | title = Could the coronavirus trigger post-viral fatigue syndromes?|last = Wilson | first = Clare | authorlink= | date = Apr 15, 2020 | website = New Scientist|language=en-US|archive-url=|archive-date=|access-date=2020-05-08}}</ref> ''New Scientist'' By: Clare Wilson. (April 15, 2020) Conditions like chronic fatigue syndrome have been linked to viral infections, so it’s possible that the covid-19 virus may go on to trigger similar conditions. '''Coronavirus could cause secondary illnesses including chronic fatigue syndrome, experts warn'''<ref>{{Cite news | url=https://www.telegraph.co.uk/global-health/science-and-disease/coronavirus-could-cause-secondary-illnesses-including-chronic/ | title = Coronavirus could cause secondary illnesses including chronic fatigue syndrome, experts warn|last = Newey|first = Sarah | date = 2020-05-02|work=The Telegraph|access-date=2020-05-08|language=en-GB|issn=0307-1235}}</ref> ''The Telegraph'' By: Sarah Newey. (May 2, 2020) Covid-19 may trigger post-viral fatigue syndrome in some patients, experts have warned, amid growing evidence that an infection could have significant long term health repercussions. While initial reports focused on the impact that the coronavirus has on the respiratory system, a stream of medical papers published over the last few weeks suggest that the contagion can get deep into our vascular system and even our brains. “Based on my experience with Sars, I am deeply concerned that our definition of ‘recovered’ is far too narrow. It’s likely that some patients will experience chronic fatigue syndromes for months or even years after an initial infection,” Dr Moldofsky told The Telegraph. Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), triggers symptoms including extreme fatigue, unexplained muscle or joint pain, heachaches and unrefreshing sleep. A study led by Dr Moldofsky following the Sars outbreak in Canada in 2002 to 2003 also found that some patients continued to have symptoms similar to CFS/ME for years after they were diagnosed with the coronavirus, which is closely related to Sars-Cov-2. The research, published in 2011, concluded that “chronic post-Sars is characterised by persistent fatigue, diffuse myalgia, weakness, depression, and nonrestorative sleep”. The paper studied 22 post-Sars patients with ongoing health problems that prevented them from returning to work, though these people represent only about eight per cent of the 273 people diagnosed with Sars in Toronto. But another study published in the Journal of the American Medical Association in 2009 found that 40 per cent of 369 Sars survivors studied in China reported a “chronic fatigue problem”, while 27 per cent met the US Centers for Disease Control and Prevention definition for CFS/ME. '''Coronavirus Is Leaving People With Serious Fatigue – What Can You Do About It'''<ref>{{Cite web |last = Hinde | first =Natasha | title = Coronavirus Is Leaving People With Serious Fatigue - What Can You Do About It|url=https://www.huffingtonpost.co.uk/entry/coronavirus-could-leave-you-with-symptoms-of-post-viral-fatigue_uk_5eb3e88dc5b6526942a29df | date = May 11, 2020|website =Huffington Post}}</ref> ''Huffington Post'' By: Natasha Hinde. (May 11, 2020) "While it’s possible some people with the virus will go on to have post-viral fatigue syndrome, it’s too early to be sure of a link. However, studies have suggested this has happened before in past outbreaks. One study from 2011 looked at 22 people who had ongoing health problems after the SARS outbreak in Toronto, Canada, and couldn’t return to work. The participants tended to have disturbed sleep, daytime fatigue, pain and weakness in the muscles, and depression, which researchers concluded were symptoms of a chronic post SARS infection syndrome. “These symptoms were very reminiscent of CFS/ME,” one of the lead researchers, Dr Harvey Moldofsky, told New Scientist. Another study of 233 SARS survivors, a year after the outbreak in Hong Kong, found 40% reported some degree of chronic fatigue and 27% met diagnostic criteria for chronic fatigue syndrome. While we don’t know for sure the causes of CFS/ME, there are a number of theories about what might trigger it – one of which is viral infections." "What experts do agree on is that people experiencing fatigue after suspected coronavirus need to listen to their bodies – if you push yourself too hard too soon, this may slow your recovery. Key to all this, says Dr Shepherd, is activity management. This doesn’t mean going to bed and staying there, nor does it mean going on a 5k run. It’s about not doing too much or too little, but instead small chunks of physical activity – a five minute walk around the garden, a rest, some mental activity, and a rest. “You certainly can’t exercise your way out of this,” he adds."
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