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Fatigue reduction diet
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The '''Fatigue Reduction Diet''' or '''FRD''' was developed for [[cancer-related fatigue]] in 2014. It is not widely used and there are no studies on the effects of the FRD on patients with [[ME/CFS]].<ref name="Zick2016" /> The Fatigue Reduction Diet is a [[healthy, balanced diet]] that contains high levels of fruit, vegetables, whole grains, and [[omega 3 fatty acid]]-rich foods (for example fish, nuts and seeds), and low overall fat and high fiber.<ref name="Zick2016" /><ref name="pres" /> Following the Fatigue Reduction Diet lead patients to increase their intake of: * Fruit * Leafy green vegetables * Yellow/orange vegetables * Tomatoes * Fish * Nuts and seeds * Whole grains<ref name="Zick2016" /> == Theory == The FRD is regarded as an [[Anti-inflammatory diets|anti-inflammatory diet]], and inflammation has been found in [[ME/CFS]] patients, including [[neuroinflammation]] in parts of the brain. It is also rich in [[antioxidant]]s, which may be beneficial. ==Evidence== The FRD was originally tested with a 3 month pilot study of just 15 fatigued breast cancer survivors, with an average age of early 60s, all of which had low fruit and vegetable intake, and none of which had fatigue caused by [[ME/CFS]] or other illness.<ref name="Zick2016" /><ref name="pres">{{Cite web | url = https://medicine.umich.edu/sites/default/files/content/downloads/Suzanna%20Zick-%20Friday%20Afternoon%20-%20Using%20Diet%20to%20Combat%20Persistent%20Fatigue%20in%20Cancer.pdf | access-date=2021-12-28 | website = Department of Family Medicine UMHS | title = Fatigue Reduction Diet in Breast Cancer Survivors: A Pilot Randomized Clinical Trial | last = Zich | first = Susanna}}</ref> The Fatigue Reduction Diet was compared to a to more general healthy balanced diet and was found to improve sleep and reduce fatigue in the cancer survivors. Blood analysis of cancer survivors on the Fatigue Reduction Diet found that reduction in fatigue was linked to increased [[Eicosapentaenoic acid|EPA]] intake and improved [[Omega 3 fatty acid hypothesis|omega 3 to omega 6 ratio]].<ref name="Zick2016" /> Participants in the pilot study had an average [[Brief Fatigue Inventory]] score of 5.4, such reduced to 3 after 3 months on the Fatigue Reduction Diet.<ref name="Zick2016" /> There are no studies on the effects of the FRD on patients with [[ME/CFS]]. ==Risks and safety== Largely unknown for ME/CFS patients. ==Costs and availability== Foods are widely available and relatively affordable for most people. ==See also== *[[Anti-inflammatory diets]] *[[Healthy, balanced diet]] *[[Eicosapentaenoic acid]] (EPA) *[[Omega 3 fatty acid hypothesis]] ==Notable studies == *2016, Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial<ref name="Zick2016">{{Cite journal | title = Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial | date = Jan 2017| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480210/|journal=Breast cancer research and treatment|volume=161|issue=2 | pages = 299β310 | last = Zick | first = Suzanna Maria | author-link = | last2 = Colacino | first2 = Justin | authorlink2 = | last3 = Cornellier | first3 = Maria | authorlink3 = | last4 = Khabir | first4 = Tohfa | authorlink4 = | last5 = Surnow | first5 = Katie | authorlink5 = | last6 = Djuric | first6 = Zora | authorlink6 = |doi=10.1007/s10549-016-4070-y|pmc=5480210|pmid=27913933|access-date=|issn=0167-6806|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480210/ (Full text)] *2019, Anti-Inflammatory Diets and Fatigue<ref name="anti-inflammatory">{{Cite journal | title = Anti-Inflammatory Diets and Fatigue | date = 2019-09-30| url = https://doi.org/10.3390/nu11102315|journal=Nutrients|volume=11|issue=10 | pages = 2315 | last = HaΓ | first = Ulrike | last2 = Herpich | first2 = Catrin | last3 = Norman | first3 = Kristina|doi=10.3390/nu11102315|pmc=PMC6835556|pmid=31574939|issn=2072-6643}}</ref> - [https://www.mdpi.com/2072-6643/11/10/2315/htm (Full text)] *2019, Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers<ref name="Park2019">{{Cite journal | last = Park | first = Hye Youn | author-link = | last2 = Jeon | first2 = Hong Jun | authorlink2 = | last3 = Bang | first3 = Young Rong | authorlink3 = | last4 = Yoon | first4 = In-Young | authorlink4 = | date = January 2019 | title = Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035/|journal=Psychiatry Investigation|volume=16|issue=1 | pages = 71β79|doi=10.30773/pi.2018.10.26|issn=1738-3684|pmc=6354035|pmid=30605994|access-date=|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035/ (Full text)] ==Learn more== *[https://medicine.umich.edu/sites/default/files/content/downloads/Suzanna%20Zick-%20Friday%20Afternoon%20-%20Using%20Diet%20to%20Combat%20Persistent%20Fatigue%20in%20Cancer.pdf Fatigue Reduction Diet in Breast Cancer Survivors: A Pilot Randomized Clinical Trial] - Summary presentation ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Dietsββ]] [[Category:Antioxidants]] [[Category:Anti-inflammatories]]
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