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The '''London criteria''' is a definition of [[Myalgic Encephalomyelitis]] for use in research, first published in 1994<ref name="Londoncriteria">{{Cite web|url=https://www.meassociation.org.uk/2011/02/london-criteria-for-m-e/|via=[[The ME Association]]|access-date=2018-08-30|first = EG|last = Dowsett | authorlink = Elizabeth Dowsett | first2 = E | last2 = Goudsmit | authorlink2 = Ellen Goudsmit | first3 = A | last3 = Macintyre | authorlink3 = Anne MacIntyre | first4 = C | last4 = Shepherd | authorlink4 = Charles Shepherd|display-authors=etal | title = London criteria for M.E.|work=Report from The National Task Force on Chronic Fatigue Syndrome (CFS), Post Viral Fatigue Syndrome (PVFS), Myalgic Encephalomyelitis (ME)|publisher=Westcare | date = 1994 | pages = 96-98}}</ref> and updated in 2014.<ref name="London2014">{{Citation | url =http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-url=http://web.archive.org/web/20150923181011/http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-date=2015-09-23|url-status=dead | title = Myalgic Encephalomyelitis (ME). Criteria and clinical guidelines. 2014 | date = Oct 15, 2014|last = Howes | first = Sandra | authorlink = Sandra Howes | last2 = Goudsmit | first2 = Ellen M.|author2-link=Ellen Goudsmit | last3 = Shepherd | first3 = Charles |author3-link=Charles Shepherd}}</ref><ref name="LondonME2014copy">{{Citation | url =https://www.meassociation.org.uk/2016/10/a-copy-of-the-london-criteria-as-revised-in-2014-archived-here-for-reference-purposes-15-october-2016/ | title = A copy of the 'London Criteria for M.E. as revised in 2014 {{!}} archived here for reference purposes {{!}} 15 October 2016 | date = Oct 15, 2016|last = Howes | first = Sandra | authorlink = Sandra Howes | last2 = Goudsmit | first2 = Ellen M.|author2-link=Ellen Goudsmit | last3 = Shepherd | first3 = Charles |author3-link=Charles Shepherd|access-date=2021-11-05 | website = [[The ME Association]]|url-status=live|archive-url=https://www.researchgate.net/profile/Ellen_Goudsmit/publication/260987521_Criteria2014_ME/links/0deec532ecc9466542000000/Criteria2014-ME|archive-date=2016}}</ref> It provides operational criteria for the diagnosis of myalgic encephalomyelitis corresponding to the clinical description of the disease by renowned ME-expert Melvin Ramsay. Central elements of the London criteria are post-exertional muscle fatigue, neurocognitive impairment and fluctuation of symptoms, usually precipitated by physical or mental exercise. ==Definition== All patients should fulfill the following five criteria: # A new onset of significantly abnormal levels of [[muscle fatigability]] and/or [[muscle weakness]], [[post-exertional malaise|precipitated by relatively minor levels of activity]]. Symptoms typically worsen during the next 24-48 hours. # The presence of symptoms indicating the involvement of the [[brain]] and [[central nervous system]] (e.g. [[memory problems|impaired short-term memory]] and [[attention deficit|concentration]], [[sleep dysfunction|disturbed sleep]] patterns, [[balance problems]]). # Periods of [[poor circulation|impaired circulation]] compatible with [[autonomic dysfunction]] (e.g. [[facial pallor]], disturbances in thermoregulation including [[excessive sweating|inappropriate sweating]] and [[temperature sensitivity|sensitivity to both heat and cold]]; [[postural hypotension]] and/or [[orthostatic intolerance]]). # [[Fluctuating illness|Fluctuation of symptoms, from hour to hour and day to day]]. # These symptoms must have been present during the past three months (to exclude patients with the debility which often follows illnesses such as influenza). == Authors == * 1994 version authors: [[Elizabeth Dowsett]], [[Ellen Goudsmit]], [[Anne MacIntyre]] , and [[Charles Shepherd]] * 2014 version authors: [[Sandra Howes]], [[Ellen Goudsmit]], and [[Charles Shepherd]] ==Citation== {{Citation | url =http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-url=http://web.archive.org/web/20150923181011/http://www.axfordsabode.org.uk/me/mecrit2014.htm|archive-date=2015-09-23|url-status=dead | title = Myalgic Encephalomyelitis (ME). Criteria and clinical guidelines. 2014 | date = Oct 15, 2014|last = Howes | first = Sandra | authorlink = Sandra Howes | last2 = Goudsmit | first2 = Ellen M.|author2-link=Ellen Goudsmit | last3 = Shepherd | first3 = Charles |author3-link=Charles Shepherd}} == History == === The first version === The first version of the London criteria was formulated by [[Elizabeth Dowsett]], [[Ellen Goudsmit]], Anne MacIntyre and [[Charles Shepherd]] in 1993. A shortened version was published a year later in the report from the National Task Force on ME.<ref name="Londoncriteria"/> The criteria focused on post-exertional muscle fatigue, neurocognitive impairment and fluctuation of symptoms, usually precipitated by physical or mental exercise. Autonomic and immunological symptoms were regarded as secondary. According to [[Charles Shepherd]], the London criteria were developed "in order to try and persuade researchers to carry out research into [[Melvin Ramsay|Ramsay]]-described ME. This was obviously at a time when the medical profession had decided to rename and redefine ME as CFS and (if possible) put a very thick red line through the term ME."<ref name="Londoncriteria"/> The criteria were written for British patients organizations and used in several studies<ref>McCue P, Martin CR, Buchanan T, Rodgers T, Scholey AB. An investigation into the psychometric properties of the Hospital Anxiety and Depression Scale in individuals with chronic fatigue syndrome. Psychol Health Med. 2003;8:425-439.</ref><ref>Perrin RN, Edwards J, Hartley P. An evaluation of the effectiveness of osteopathic treatment on symptoms associated with myalgic encephalomyelitis. A preliminary report. J Med Eng Technol. 1998;22(1)1-13.</ref> - most notably the study on brainstem blood perfusion by Costa et al. (1995)<ref>Costa DC, Tannock C, Brostoff J. Brainstem perfusion is impaired in patients with chronic fatigue syndrome. Q J Med. 2005;88:767-773.</ref>. The criteria however failed to get wider traction in the research community, as most journals and funders preferred to use the [[Centers for Disease Control|CDC]]-formulated chronic fatigue syndrome-criteria. === The updated London criteria === With the publication of the [[International Consensus Criteria]] (ICC) in 2011, alternative criteria for the diagnosis of ME became available for researchers and clinicians. The ICC were formulated by ME-experts from 12 different countries, using a Delphi-type process. Although the ICC have been validated in research<ref>{{Cite journal | last = Johnston | first = Samantha | last2 = Staines | first2 = Donald | last3 = Marshall-Gradisnik | first3 = Sonya | date = May 2016 | title = Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients|url=https://pdfs.semanticscholar.org/104e/47348a0d51cf0970b8d15f3ec387aa943f5d.pdf | journal=Clinical Epidemiology | pages = 97|doi=10.2147/clep.s96797|issn=1179-1349|volume=|via= | authorlink2 = Donald Staines | authorlink3 = Sonya Marshall-Gradisnik}}</ref>, several criticisms have arisen about its use. [[Leonard Jason]] for example noted that it is not clear if all five elements of what the ICC calls post-exertional neuroimmune exhaustion (PENE) should be present or not. A 2013 paper by [[Abigail Brown|Brown]] et al. demonstrated that the ICC identifies a patient group with more psychiatric disorders than the [[Fukuda criteria|Fukuda]] (CFS) criteria.<ref>{{Cite journal|last = Brown | first = Abigail A. | last2 = Jason | first2 = Leonard A. | last3 = Evans | first3 = Meredyth A. | last4 = Flores | first4 = Samantha | date = 2013-03-01 | title = Contrasting Case Definitions: The ME International Consensus Criteria vs. the Fukuda et al. CFS Criteria|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215640/|journal=North American Journal of Psychology|volume=15|issue=1|pages=103–120|issn=1527-7143|pmc=|pmid=25364305|via= | author-link = Abigail Brown | authorlink2 = Leonard Jason | authorlink3 = Meredyth Evans}}</ref> By utilizing a wide array of symptoms in the diagnosis of ME, the ICC seems to capture a different set of patients than those originally described by [[Melvin Ramsay|Ramsay]]. Furthermore, [[Paresis|muscle weakness]] after minimal exercise is not explicitly mentioned in the ICC-description of PENE.<ref>{{Cite journal | last = McManimen | first = Stephanie L. | last2 = Sunnquist | first2 = Madison L. | last3 = Jason | first3 = Leonard A. | date = 2016-08-01 | title = Deconstructing post-exertional malaise: An exploratory factor analysis|url=https://www.ncbi.nlm.nih.gov/pubmed/27557649|journal=Journal of Health Psychology|pages=1359105316664139|doi=10.1177/1359105316664139|issn=1461-7277|pmc=|pmid=27557649|volume=|via= | author-link = Stephanie McManimen | authorlink2 = Madison Sunnquist | authorlink3 = Leonard Jason}}</ref> The London criteria were updated in 2009<ref name="Goudsmit2009">{{Cite journal|last = Goudsmit | first = Ellen | first2 = Charles | last3 = Dancey | first3 = Christine | first4 = Sandra | date = 2009-01-01 | title = ME: Chronic fatigue syndrome or a distinct clinical entity?|url=https://www.researchgate.net/publication/234101217_ME_Chronic_fatigue_syndrome_or_adistinct_clinical_entity|journal=Health Psychology Update|volume=18|pages=26–33|via= | last2 = Shepherd | last4 = Howes}}</ref> and once more in 2014<ref name="London2014" />, to provide research criteria that capture the clinical picture of ME as described by Ramsay and the pre-CFS literature. This updated version of the London Criteria added "impaired circulation compatible with autonomic dysfunction" as a major criterium and recommends the use of the Profile of Fatigue Related Symptoms (PFRS)<ref name="Ray1992">{{Cite journal|last = Ray|first = Colette | last2 = Weir | first2 = William R.C. | authorlink2 = William Weir | last3 = Phillips | first3 = Sarah | last4 = Cullen | first4 = Sarah | date = Oct 1992 | title = Development of a measure of symptoms in chronic fatigue syndrome: The profile of fatigue-related symptoms (PFRS)|url=https://www.tandfonline.com/doi/abs/10.1080/08870449208404293|journal=Psychology & Health|language=en|volume=7|issue=1|pages=27–43|doi=10.1080/08870449208404293|issn=0887-0446|via=|pmid= | pmc= }}</ref> in making the diagnosis of ME. Authors of the 2014 version were [[Ellen Goudsmit]], [[Charles Shepherd]] and [[Sandra Howes]]. == Criticism == The citation for the original London criteria typically given is:<br> EG Dowsett, E Goudsmit, A Macintyre, C Shepherd, et al., London criteria for M.E., Report from The National Task Force on Chronic Fatigue Syndrome (CFS), Post Viral Fatigue Syndrome (PVFS), Myalgic Encephalomyelitis (ME). Westcare, 1994, pp. 96-98. However, [[Malcolm Hooper]] and [[Margaret Williams]] both point out that this report does not include any author names.<ref name="Williams">{{Cite web|url=https://www.margaretwilliams.me/2005/cs-discrepancy-re-lc-on-co-cure.pdf | first = Margaret|last = Williams | authorlink = Margaret Williams | date = May 18, 2005 | title = Correct Citation for the "London" criteria?}}</ref> === Use in the PACE-trial === The London criteria came back into the center of attention when [[Peter White|White]] et al. announced they were going to use the London criteria to diagnose ME patients in the [[PACE trial]].<ref>{{Cite journal|last = White | first = Peter D | last2 = Sharpe | first2 = Michael C | last3 = Chalder | first3 = Trudie | last4 = DeCesare | first4 = Julia C | last5 = Walwyn | first5 = Rebecca | date = 2007-03-08 | title = Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy|url=http://dx.doi.org/10.1186/1471-2377-7-6|journal=BMC Neurology|volume=7|issue=1|doi=10.1186/1471-2377-7-6|issn=1471-2377}}</ref> The actual version used in the [[PACE trial]] was however a modified version of the London criteria, not approved by any of the authors. [[Ellen Goudsmit]] for example wrote: “The version used in the PACE trial was not written by any of those who were involved with the London criteria. I’ve seen the manual and don’t recognize it.”<ref name="Londoncriteria" /> The [[PACE trial|PACE]] authors referred to the report from the National Task Force on ME, yet not all details of the London Criteria were published in that report.The directive to exclude psychological disorders for example was not mentioned. In the 1993 version, made available online by [[Charles Shepherd]] and the ME Association, the following passage was included:<blockquote> “Of particular importance is to eliminate chronic fatigue primarily associated with psychological factors. If there are signs of persistent anhedonia, apathy, low self-esteem, feelings of worthlessness and guilt, the possibility: of primary depressive illness should be actively considered and, if there is any doubt whatsoever, the subject eliminated from the research study.”<ref name="Londoncriteria" /></blockquote>The published data of the [[PACE trial]] do not make clear if psychological disorders had been excluded, as the original London criteria required.<ref>{{Cite journal|last = Goudsmit | first = Ellen | last2 = Howes | first2 = Sandra | date = 2017-05-29 | title = Bias, misleading information and lack of respect for alternative views have distorted perceptions of myalgic encephalomyelitis/chronic fatigue syndrome and its treatment|url=http://journals.sagepub.com/doi/pdf/10.1177/1359105317707216|journal=Journal of Health Psychology|language=en|volume=22|issue=9|pages=1159–1167|doi=10.1177/1359105317707216|issn=1359-1053}}</ref> According to [[Ellen Goudsmit|Goudsmit]], the fact that the London criteria (LC) were used in the [[PACE trial]], instigated a backlash against the criteria among ME advocates: <blockquote>"The LC were generally considered a good thing when the study was published in 1995. It became an issue only when the LC were included in the protocol for the PACE Trial. This introduced a political element, i.e. some argued that if one could show that the LC were no good, what was it doing in an expensive, government funded trial and the only proper action was to stop that trial. We all got that. Activists therefore began questioning everything they could about the LC."<ref name="Londoncriteria" /></blockquote>[[Malcolm Hooper]] had for example written: <blockquote>The 'London Criteria' have no known authors; they have never been published; there is no methods paper which specifically describes them as a "case definition"; they have never been approved nor have they even been finally defined (there are various versions); they have never been validated and they are not on PubMed thus are not available for scrutiny so they cannot be accessed for comparison. This means that [[Peter White|Professor White]] was essentially able to create his own version of the London Criteria.<ref>{{Cite news | url=https://forums.phoenixrising.me/index.php?threads/pace-study-and-oxford-criteria.8880/page-2 | title = PACE study and oxford criteria|work=Phoenix Rising ME / CFS Forums|access-date=2018-08-30|language=en-US|last = Hooper | first = Malcolm | authorlink = Malcolm Hooper | date = |archive-url=|archive-date=|url-status=}}</ref></blockquote> ==See also== *[[Charles Shepherd]] *[[Definitions of myalgic encephalomyelitis and chronic fatigue syndrome]] *[[Elizabeth Dowsett]] *[[Ellen Goudsmit]] *[[Anne MacIntyre]] *[[Sandra Howes]] ==Learn more== *2014, [https://www.researchgate.net/profile/Ellen_Goudsmit/publication/260987521_Criteria2014_ME/links/0deec532ecc9466542000000/Criteria2014-ME "London Criteria for M.E." as revised in 2014] *2017, [https://www.jscimedcentral.com/ChronicDiseases/chronicdiseases-2-1013.pdf A Comparison of Case Definitions for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome] ==References== {{Reflist}} [[Category:Definitions]]
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