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Myelin basic protein
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{{stub}} '''Myelin basic proteins''' or '''MBP''' is a group of seven proteins produced from a single gene, and are found in the [[central nervous system|central]] and [[peripheral nervous system]].<ref name="Achiron2007">{{Cite book | title = Autoantibodies | edition = Second | chapter = 76 - MYELIN ASSOCIATED ANTIBODIES: MYELIN-ASSOCIATED GLYCOPROTEIN AUTOANTIBODIES, MYELIN BASIC PROTEIN AUTOANTIBODIES AND MYELIN PROTEOLIPID AUTOANTIBODIES IN NEUROLOGIC DISEASES|date=2007-01-01|url=https://www.sciencedirect.com/science/article/pii/B9780444527639500809|pages=619β626 |last=Achiron|first=A. |last2=Miron|first2=S.|isbn=978-0-444-52763-9|location=Burlington|publisher=Elsevier|editor-last=Shoenfeld|editor-first=Yehuda|editor2-last=Gershwin|editor2-first=M. Eric|editor3-last=Meroni|editor3-first=Pier Luigi}}</ref> The gene encoding myelin basic protein is also referred to as MBP.<ref name="genecards">{{Cite web | access-date = 2023-12-31 | url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=MBP | title = MBP Gene - Myelin basic protein - Gene card | website = Gene cards}}</ref> ==Function== Myelin basic protein (MBP) is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin,<ref name="Boggs2006">{{Cite journal|title=Myelin basic protein: a multifunctional protein|date=2006-09-01|url=https://link.springer.com/article/10.1007/s00018-006-6094-7|journal=Cellular and Molecular Life Sciences CMLS|volume=63|issue=17|pages=1945β1961|last=Boggs|first=J. M.|language=en|doi=10.1007/s00018-006-6094-7|issn=1420-9071}}</ref> and MBP levels in [[cerebral spinal fluid]] are considered as a marker of active demyelination.<ref name="CSF-test">{{Cite web|url=https://medlineplus.gov/ency/article/003370.htm|title=CSF myelin basic protein|website=Medline Plus Medical Encyclopedia|language=en|access-date=2023-12-30}}</ref><ref name="genecards"/> ==ME/CFS== == Notable studies == * 2023, Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Xu2023">{{Cite journal|title=Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|date=2023-11-27|url=https://pubs.acs.org/doi/full/10.1021/acs.biochem.3c00433|journal=Biochemistry|last=Jensen|first=Michael Anthony|author-link=Michael Jensen|last2=Dafoe|first2=Miranda Lee|author-link2=Miranda Dafoe|last3=Wilhelmy|first3=Julie|author-link3=Julie Wilhelmy|last4=Cervantes|first4=Layla|author-link4=Layla Cervantes|last5=Okumu|first5=Anna N.|last6=Kipp|first6=Lucas|last7=Nemat-Gorgani|first7=Mohsen|last8=Davis|first8=Ronald Wayne | authorlink8 = Ronald Davis|doi=10.1021/acs.biochem.3c00433|pmid=38011893|issn=1520-4995}}</ref> - [https://pubs.acs.org/doi/full/10.1021/acs.biochem.3c00433 (Full text)] ==See also== * [[Myelin]] * [[Multiple sclerosis]] * [[Genetics of chronic fatigue syndrome]] ==Learn more== *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=MBP Myelin basic protein Gene] - Gene cards * [https://medlineplus.gov/ency/article/003370.htm CSF myelin basic protein] - MedLine Plus ==References== {{reflist}} [[Category:Biochemistry and cell biology]] [[Category:Genes]] [[Category:Proteins]]
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