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Serotonin hypothesis
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{{stub}} The '''central fatigue''' or '''serotonin hypothesis''' of [[ME/CFS]] states that excessive levels of the [[neurotransmitter]] [[serotonin]] are involved in the pathophysiology of ME/CFS, and are directly responsible for symptoms such as [[fatigue]].<ref name="Meeusen2006"/> ==Theory== In 2024, Lee and colleagues published research stating that they had developed an animal model of ME/CFS involving serotonin hyperactivity and CFS-like symptoms, but this has not yet been replicated.<ref name="Lee2024"/> ==Evidence== ==Treatment== ==Notable studies == * 2024, Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology<ref name="Lee2024">{{Cite journal|title=Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology|date=2024-01-08|url=https://doi.org/10.1186/s12967-023-04808-x|journal=Journal of Translational Medicine|volume=22|issue=1|pages=34|last=Lee|first=Jin-Seok|last2=Kang|first2=Ji-Yun|last3=Park|first3=Samuel-Young|last4=Hwang|first4=Seung-Ju|last5=Bae|first5=Sung-Jin|last6=Son|first6=Chang-Gue|doi=10.1186/s12967-023-04808-x|pmc=PMC10773012|pmid=38191373|issn=1479-5876}}</ref> - [https://link.springer.com/article/10.1186/s12967-023-04808-x (Full text)] * 2006, Central fatigue: the serotonin hypothesis and beyond<ref name="Meeusen2006">{{Cite journal|title=Central Fatigue|date=2006-10-01|url=https://doi.org/10.2165/00007256-200636100-00006|journal=Sports Medicine|volume=36|issue=10|pages=881β909|last=Meeusen|first=Romain|last2=Watson|first2=Philip|last3=Hasegawa|first3=Hiroshi|last4=Roelands|first4=Bart|last5=Piacentini|first5=Maria F.|language=en|doi=10.2165/00007256-200636100-00006|issn=1179-2035}}</ref> - [https://www.researchgate.net/profile/Romain-Meeusen-2/publication/6789461_Central_fatigue_the_serotonin_hypothesis_and_beyond/links/0912f50c2eea90d06d000000/Central-fatigue-the-serotonin-hypothesis-and-beyond.pdf (Full text)] ==See also== * [[Serotonin]] ==Learn more== ==References== {{reflist}} [[Category:Medical hypotheses]]
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