Deadlock quartet: Difference between revisions
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The '''deadlock quartet''' is a combination of four nutrients used to overcome a proposed "deadlock" in the [[methylation cycle]].<ref name="PR-symptoms2013">{{Cite web|access-date=2022-05-19|title=Symptoms By Deadlock Quartet and other nutrients | last = Freddd|website=[[Phoenix Rising]]|date=2013-02-07|url=https://forums.phoenixrising.me/threads/symptoms-by-deadlock-quartet-and-other-nutrients.27482/}} | The '''deadlock quartet''' is a combination of four nutrients used to overcome a proposed "deadlock" in the [[methylation cycle]].<ref name="PR-symptoms2013">{{Cite web | access-date=2022-05-19 | title = Symptoms By Deadlock Quartet and other nutrients | last = Freddd|website=[[Phoenix Rising]] | date = 2013-02-07 | url = https://forums.phoenixrising.me/threads/symptoms-by-deadlock-quartet-and-other-nutrients.27482/}}</ref><ref name="Methylcyclehypothesis" /> | ||
</ref><ref name="Methylcyclehypothesis" /> | |||
The deadlock quartet consists of: | The deadlock quartet consists of: | ||
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==Evidence== | ==Evidence== | ||
There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by [[Phoenix Rising]] forum member Freddd, based on work by ME/CFS patient [[Rich Van Konynenburg]].<ref name="Methylcyclehypothesis">{{Cite web | There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by [[Phoenix Rising]] forum member Freddd, based on work by ME/CFS patient [[Rich Van Konynenburg]].<ref name="Methylcyclehypothesis">{{Cite web | title = Status of methylation cycle model and treatment | date = Sep 19, 2009|last =Van Konynenburg|first = Rich | authorlink = Rich Van Konynenburg| website = Phoenix Rising| url =https://forums.phoenixrising.me/threads/status-of-methylation-cycle-model-and-treatment.406/|access-date=2022-05-19}}</ref> | ||
The concept of a block or deadlock affecting [[energy metabolism]] is also part of the [[metabolic trap]] hypothesis, which was developed independently using the [[ME/CFS Severely Ill, Big Data Study]], and which has different proposed treatments.{{citation needed|date=2022}} | The concept of a block or deadlock affecting [[energy metabolism]] is also part of the [[metabolic trap]] hypothesis, which was developed independently using the [[ME/CFS Severely Ill, Big Data Study]], and which has different proposed treatments.{{citation needed | date = 2022}} | ||
==Clinicians== | ==Clinicians== | ||
==Risks and safety== | ==Risks and safety== | ||
Largely unknown since clinicial trials have not taken place. Cyanocobalamin has significant safety risks, including the loading of [[potassium]] levels.<ref name="PMC5312744">{{Cite journal|title=Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms|date=Feb 2017|url=https://pubmed.ncbi.nlm.nih.gov/28223907/|journal=Integrative Medicine (Encinitas, Calif.)|volume=16|issue=1|pages=42–49 | last = Paul|first = Cristiana | | Largely unknown since clinicial trials have not taken place. Cyanocobalamin has significant safety risks, including the loading of [[potassium]] levels.<ref name="PMC5312744">{{Cite journal | title = Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms | date = Feb 2017 | url = https://pubmed.ncbi.nlm.nih.gov/28223907/|journal=Integrative Medicine (Encinitas, Calif.)|volume=16|issue=1 | pages = 42–49 | last = Paul|first = Cristiana | authorlink = | last2 = Brady | first2 = David M. | authorlink2 = | last3 = | first3 = | authorlink3 = | last4 = | first4 = | author-link4 = | last5 = | first5 = | author-link5 = |doi=|pmc=5312744|pmid=28223907|access-date=|issn=1546-993X|quote=|via=}}</ref> Both cyanocobalamin and hydroxocobalamin are available as supplements and in other forms, including injections of higher doses as a perscription drug.<ref name="cyano">{{Cite web | url = https://www.drugs.com/pro/cyanocobalamin.html | title = Cyanocobalamin - FDA prescribing information, side effects and uses|website=Drugs.com|language=en|access-date=2022-05-19}}</ref><ref name="hydrox">{{Cite web | url = https://www.drugs.com/mtm/hydroxocobalamin-injection.html | title = Hydroxocobalamin injection Uses, Side Effects & Warnings|website=Drugs.com|language=en|access-date=2022-05-19}}</ref> Allergies and anaphylatic shock also occur in some people given cyanocobalamin or other B12 forms.<ref name="PMC5312744" /> | ||
==Costs and availability== | ==Costs and availability== | ||
Latest revision as of 00:56, April 2, 2023
The deadlock quartet is a combination of four nutrients used to overcome a proposed "deadlock" in the methylation cycle.[1][2]
The deadlock quartet consists of:
- cyanocobalamin - a form of vitamin B12
- Hydroxocobalamin - a form of vitamin B12
- Folic acid
- Folinic acid
Theory[edit | edit source]
A hypotheical four-way "deadlock" in the methylation process is believed to cause energy limitations due to impaired metabolism.
Evidence[edit | edit source]
There is no peer-reviewed evidence in support of either a four-way deadlock in methylation or in the use of the deadlock quartet to treat it. The deadlock quartet was developed by Phoenix Rising forum member Freddd, based on work by ME/CFS patient Rich Van Konynenburg.[2]
The concept of a block or deadlock affecting energy metabolism is also part of the metabolic trap hypothesis, which was developed independently using the ME/CFS Severely Ill, Big Data Study, and which has different proposed treatments.[citation needed]
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Largely unknown since clinicial trials have not taken place. Cyanocobalamin has significant safety risks, including the loading of potassium levels.[3] Both cyanocobalamin and hydroxocobalamin are available as supplements and in other forms, including injections of higher doses as a perscription drug.[4][5] Allergies and anaphylatic shock also occur in some people given cyanocobalamin or other B12 forms.[3]
Costs and availability[edit | edit source]
See also[edit | edit source]
- Methylation cycle hypothesis (Freddd's protocol)
- Rich Van Konynenburg
Learn more[edit | edit source]
- Vitamin B12 - Office of Dietary Supplements
- Cyanocobalamin - FDA prescribing information, side effects - drugs.com
- Hydroxocobalamin (injection): Uses, Side Effects & Warnings - drugs.com
References[edit | edit source]
- ↑ Freddd (February 7, 2013). "Symptoms By Deadlock Quartet and other nutrients". Phoenix Rising. Retrieved May 19, 2022.
- ↑ 2.0 2.1 Van Konynenburg, Rich (September 19, 2009). "Status of methylation cycle model and treatment". Phoenix Rising. Retrieved May 19, 2022.
- ↑ 3.0 3.1 Paul, Cristiana; Brady, David M. (February 2017). "Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms". Integrative Medicine (Encinitas, Calif.). 16 (1): 42–49. ISSN 1546-993X. PMC 5312744. PMID 28223907.
- ↑ "Cyanocobalamin - FDA prescribing information, side effects and uses". Drugs.com. Retrieved May 19, 2022.
- ↑ "Hydroxocobalamin injection Uses, Side Effects & Warnings". Drugs.com. Retrieved May 19, 2022.
