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Acetaminophen
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[[File:Paracetamol.jpg|alt=paracetamol tablets|thumb|Acetaminophen or paracetamol. Photo by Michelle Tribe.]] '''Acetaminophen''', also known as '''paracetamol''', '''panadol''' or '''tylenol''', is a mild [[analgesic]] used to treat mild to moderate [[pain]] and [[fever]]. It is most commonly adminstered by mouth (in both soluble and tablet form) but can also be administered rectally or intravenously. Effects last between two and four hours.<ref>{{Cite web | url = https://www.drugs.com/monograph/acetaminophen.html | title = Acetaminophen Monograph for Professionals | website = Drugs.com|language=en | access-date = 2019-04-27}}</ref> ==Use in chronic fatigue syndrome== Acetaminophen is commonly used alone and in combination with other painkillers to alleviate painful syptoms such as [[sore throat]], [[headache]], [[muscle pain]], and [[joint pain]], as well as [[low-grade fever]] relief. ==Combinations== Acetaminophen is commonly paired with [[opiates]] such as [[codeine]] or [[tramadol]], and/or with [[Nonsteroidal anti-inflammatory drug|NSAIDs]] such as [[ibuprofen]], [[naproxen]] or [[diclofenac]]. This can help relieve moderate to strong pain. ==Evidence== The [[Canadian Consensus Criteria]] suggests using acetaminophen for [[ME/CFS]] as a "baseline analgesic", stating that it has a weak effect but few side effects.<ref name="CanadianConsensusCriteria">{{Citation | last =Carruthers | first1 = Bruce M. | author-link1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | author-link2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | author-link3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | author-link4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | author-link5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | author-link6 = Martin Lerner | last7 = Bested | first7 = Alison C. | author-link8 = Alison Bested | last8 =Flor-Henry | first8 = Pierre | author-link8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | author-link9 = Pradip Joshi | last10= Powles | first10 = AC Peter | author-link10 = A C Peter Powles | last11= Sherkey | first11 = Jeffrey A. | author-link11 = Jeffrey Sherkey | last12= van de Sande | first12 = Marjorie I. | author-link12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal =Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | date = 2003 | isbn = 9780789022073 | doi = 10.1300/J092v11n01_02 | url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf | type =pdf| pages = 10, 53-55}}</ref> ===Dose=== Suggested dose is 1-4 325mg tablets, every 4 hours as needed.<ref name="CanadianConsensusCriteria" /> ==Costs and availability== Acetaminophen is widely available at low cost. It can usually be purchased off the shelf without prescription. ==Learn more== *[https://en.wikipedia.org/wiki/Paracetamol Wikipedia - Paracetamol] *[https://www.drugs.com/acetaminophen.html Drugs.com - Acetaminophen] ==See also== *[[Analgesics|Pain relief (analgesics)]] ==References== {{Reflist}} [[Category:Potential treatments]] [[Category:Analgesics]] [[Category:Antipyretics]]
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