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Collagen
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== Biology == === Components === Collagen is made up primarily of the amino acids glycine and proline. The primary amino acid sequence of collagen is glycine-proline-X or glycine-X-hydroxyproline.<ref>{{Cite journal | last = Szulc | first = Pawel | date = Oct 2018 | title = Bone turnover: Biology and assessment tools |url =https://www.ncbi.nlm.nih.gov/pubmed/30449551 | journal = Best Practice & Research. Clinical Endocrinology & Metabolism|volume=32 | issue = 5 | pages = 725–738|doi=10.1016/j.beem.2018.05.003|issn=1878-1594|pmid=30449551 | last2 = | first2 = |pmc=|quote=|access-date=|via=}}</ref> X can be any of the other 17 amino acids. Every third amino acid is glycine.<ref name="Wu2019" /> === Co-factors === [[Vitamin C]] is a co-factor of many of the chemical reactions involved in collagen production. Vitamin C is also a [[mast cell]] stabilizer. Vitamin C deficiency can result in impaired collagen synthesis and [[scurvy]].<ref name="vitC-deficiency">https://www.statpearls.com/ArticleLibrary/viewarticle/28798</ref> === Structure === Collagen is composed of three chains that wind together to form a triple helix.<ref name="Wu2019" /> === Biosynthesis === Collagen synthesis occurs mainly in [[Fibroblast|fibroblasts]], cells whose many function is the synthesis of collagen and stroma.<ref name="Wu2019" /> Synthesis occurs in both intracellular and extracellular spaces.<ref name="Wu2019" />
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