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Diagnostic biomarker
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=== Defining a biomarker === In 2001, the [[World Health Organization]] (WHO), in coordination with the United Nations and the International Labor Organization, has defined a biomarker as βany substance, structure, or process that can be measured in the body or its products and influence or predict the incidence of outcome or disease.β<ref name="WHO, 2001" /> The Biomarkers Consortium, a major public-private biomedical research partnership, uses the 2001 [[National Institutes of Health]] (NIH) Biomarkers Definitions Working Group definition: "Biomarkers are characteristics that are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to therapeutic intervention."<ref name="NIH, 2001" /> Presently, [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] (ME/CFS) patients are diagnosed based on well-defined clinical criteria, for example, please see the Proposed Diagnostic Criteria Chart section of the [[Institute of Medicine report]]. Diagnosis also includes a process of exclusion of other causes of fatigue which can result in a delay of diagnosis.<ref name="IOM2015MECFS" /> Potential diagnostic biomarkers for [[ME/CFS]] are being explored by many researchers in the field. Below is a list of some that have been considered. They are alphabetically ordered so as not to imply some may be more promising than others.
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