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Diagnostic biomarker
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===Plasma neuropeptide Y=== Plasma levels of neuropeptide Y (NPY), a neurotransmitter in high quantity in the [[brain]], are reported to be elevated in complex multi-symptom illnesses associated with [[immune system|immunologic] dysfunction. [[Mary Ann Fletcher| Fletcher]], et al, did a study believed to be "the first in the CFS literature to report that plasma NPY is elevated [in ME/CFS] compared to healthy controls and to a fatigued comparison group, GWI [Gulf War Illness] patients. The significant correlations of NPY with stress, negative mood, general health, depression and cognitive function strongly suggest that this peptide be considered as a biomarker to distinguish subsets of CFS."<ref name=":0">{{Cite journal | last1 = Fletcher | first1 = Mary Ann | authorlink = Mary Ann Fletcher | last2 = Rosenthal | first2 = Martin | last3 = Antoni | first3 = Michael | authorlink3 =Michael Antoni | last4 = Ironson | first4 = Gail | last5 = Zeng | first5 = Xiao R | last6 = Barnes | first6 = Zachary | author-link6 = Zachary Barnes | last7 = Harvey | first7 = Jeanna M | author-link8 = Jeanna Harvey | last8 = Hurwitz | first8 = Barry | last9 = Levis | first9 = Silvina | last10 = Broderick | first10 = Gordon | author-link10 = Gordon Broderick | last11 = Klimas | first11 = Nancy G | author-link11 = Nancy Klimas | title = Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome|journal = Behavioral and Brain Functions| volume = 6 | issue = 76| pages = | date =2010|doi= 10.1186/1744-9081-6-76}}</ref> Obstacles in use: NPY is elevated in other immune illnesses such as [[rheumatoid arthritis]] (RA) and [[systemic lupus erythematosus]] (SLE). NPY varies greatly between individuals and is interdependent on other cellular and molecular components and must be viewed with data from other biomarkers.<ref name=":0" />
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