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Epstein-Barr virus
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===Antivirals=== Several [[antiviral]]s are active against EBV including [[valganciclovir]], [[valacyclovir]]<ref name="Hoshino2009">{{Cite journal | title = Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers | date = Nov 2009| url = https://pubmed.ncbi.nlm.nih.gov/19740997/|journal=Journal of Virology|volume=83|issue=22 | pages = 11857–11861 | last = Hoshino | first = Yo | author-link = | last2 = Katano | first2 = Harutaka | authorlink2 = | last3 = Zou | first3 = Ping | authorlink3 = | last4 = Hohman | first4 = Patricia | authorlink4 = | last5 = Marques | first5 = Adriana | authorlink5 = | last6 = Tyring | first6 = Stephen K. | author-link6 = | last7 = Follmann | first7 = Dean | last8 = Cohen | first8 = Jeffrey I.|doi=10.1128/JVI.01005-09|pmc=2772668|pmid=19740997|access-date=|issn=1098-5514|quote=|via=}}</ref>, [[acyclovir]]<ref name="Rafaillidis2013">{{Cite journal | title = Antiviral treatment for severe EBV infections in apparently immunocompetent patients | date = Nov 2010| url = https://pubmed.ncbi.nlm.nih.gov/20739216/|journal=Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology|volume=49|issue=3 | pages = 151–157 | last = Rafailidis | first = Petros I. | authorlink = | last2 = Mavros | first2 = Michael N. | authorlink2 = | last3 = Kapaskelis | first3 = Anastasios | authorlink3 = | last4 = Falagas | first4 = Matthew E. | author-link4 = |doi=10.1016/j.jcv.2010.07.008|pmc=|pmid=20739216|access-date=|issn=1873-5967|quote=|via=}}</ref>, and [[spironolactone]].<ref name="Verma2016">{{Cite journal | last1 = Verma | first1 = Dinesh | last2 = Thompson | first2 = Jacob | last3 = Swaminathan | first3 = Sankar| title = Spironolactone blocks Epstein–Barr virus production by inhibiting EBV SM protein function | journal =Proceedings of the National Academy of Sciences | issn = 1091-6490 | volume = 113 | issue = 13| pages = 3609–3614 | date = 2016-03-29 | doi = 10.1073/pnas.1523686113 | pmid = 26976570| url = http://www.pnas.org/content/113/13/3609}}</ref> [[Acyclovir]], an [[antiviral]] drug which inhibits (but does not destroy) herpesviruses, was shown to also inhibit the virus production. This suggests that EBV replicates via lytic replication. A theoretical [[immunotherapy]] treatment proposes that inducing [[CD1d]] expression on EBV-infected B cells could prompt effective immune suppression of EBV by natural killer T cells.<ref name="Priatel2014"/>
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