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Omega 3 fatty acid hypothesis
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===Treatment=== Puri recommends treatment with evening primrose oil, a source of GLA, and high dose EPA without DHA, such as [http://www.amazon.co.uk/Igennus-Vegepa-E-EPA-70-high-EPA/dp/B007W1JIQ2 VegEPA]. Both EPA and GLA block the conversion of AA to inflammatory [[leukotriene]]s [[eicosanoid|through various mechanisms]]. Similarly, Grey, et al, citing studies in [[rheumatoid arthritis]] point out increasing dietary Omega 3's decreases the amount of AA and [[linoleic acid]] (LA) (omega 6's that are substrates for LTB4) in the cell membrane, thus reducing LTB4 production. They note that dietary changes can take 12-18 weeks to manifest in clinical improvement.<ref>www.sciencedirect.com/science/article/pii/0306987794900469</ref> They do not distinguish between EPA and DHA supplementation.
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