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Diagnostic biomarker
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===Tilt table test results=== Tilt table tests have shown abnormalities including an average 27% drop in blood flow to the brain in one study of bedbound with severe ME and orthostatic intolerance symptoms, using an angle of just 20 degrees.<ref name="CBF2020" /> Similar abnormalities in blood flow have been found in mild and moderate ME/CFS patients.<ref>{{Cite journal | last = van Campen | first = C. (Linda) M.C. | authorlink = Linda van Campen | last2 = Verheugt | first2 = Freek W.A. | authorlink2 = | last3 = Rowe | first3 = Peter C. | authorlink3 = Peter Rowe | last4 = Visser | first4 = Frans C. | authorlink4 = Frans Visser | date = Feb 8, 2020 | title = Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography | url = https://linkinghub.elsevier.com/retrieve/pii/S2467981X20300044|journal=Clinical Neurophysiology Practice|language=en|volume=5|issue= | pages = 50β58|doi=10.1016/j.cnp.2020.01.003|pmc = 7044650|pmid=32140630|access-date=|quote=|via=}}</ref><ref name="CBF2020">{{Cite journal | last = van Campen | first = C. (Linda) M. C. | authorlink = | last2 = Rowe | first2 = Peter C. | authorlink2 = Peter Rowe | last3 = Visser | first3 = Frans C. | authorlink3 = Frans Visser | date = Jun 2020 | title = Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing | url =https://www.mdpi.com/2227-9032/8/2/169|journal=Healthcare|language=en|volume=8|issue=2 | pages = 169|doi=10.3390/healthcare8020169|pmc=|pmid=|access-date=|quote=|via=}}</ref>
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