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Hashimoto's thyroiditis (hypothyroidism)
(section)
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== Cellular hypothyroidism == Some patients may exhibit Hashimoto's hypothyroid symptoms, yet display normal ranges in their thyroid blood tests. This could be an indication of β''cellular or peripheral hypothyroidism''β, where there's a deficiency at the cellular level. While thyroid hormone production may be functioning properly, the transportation of thyroid hormone into cells will be hindered if there is mitochondrial dysfunction.<ref>{{Cite journal | last = Kelly | first = Tammas | date = Dec 2016 | title = A hypothesis on the mechanism of action of high-dose thyroid in refractory mood disorders| url = https://pubmed.ncbi.nlm.nih.gov/27876122/|journal=Medical Hypotheses|volume=97 | pages = 16β21|doi=10.1016/j.mehy.2016.09.022|issn=1532-2777|pmid=27876122}}</ref> [[Mitochondria dysfunction|Mitochondrial dysfunction]] has been implicated countless times, not only as a contributor to, but often cited as the immediate cause of ME/CFS symptoms.<ref>{{Cite journal | last = Myhill | first = Sarah | last2 = Booth | first2 = Norman E. | last3 = McLaren-Howard | first3 = John | date = 2009-01-15 | title = Chronic fatigue syndrome and mitochondrial dysfunction | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/|journal=International Journal of Clinical and Experimental Medicine|volume=2|issue=1 | pages = 1β16|issn=1940-5901|pmc=2680051|pmid=19436827}}</ref><ref>{{Cite journal | last = Tomas | first = Cara | last2 = Brown | first2 = Audrey E. | last3 = Newton | first3 = Julia L. | last4 = Elson | first4 = Joanna L. | date = 2019-03-01 | title = Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398432/|journal=PeerJ|volume=7|doi=10.7717/peerj.6500|issn=2167-8359|pmc=6398432|pmid=30847260}}</ref><ref>{{Cite journal | last = Venter | first = Marianne | last2 = Tomas | first2 = Cara | last3 = Pienaar | first3 = Ilse S. | last4 = Strassheim | first4 = Victoria | last5 = Erasmus | first5 = Elardus | last6 = Ng | first6 = Wan-Fai | last7 = Howell | first7 = Neil | last8 = Newton | first8 = Julia L. | last9 = Van der Westhuizen | first9 = Francois H. | date = 2019-02-27 | title = MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants| url = https://www.nature.com/articles/s41598-019-39060-1|journal=Scientific Reports|language=en|volume=9|issue=1 | pages = 2914|doi=10.1038/s41598-019-39060-1|issn=2045-2322}}</ref>
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