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Lysozyme
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'''Lysozyme''' or '''muramidase''' is a protein and enzyme present in tears, saliva and other bodily fluids.<ref name="MerrianWebster">{{Cite web|url=https://www.merriam-webster.com/dictionary/lysozyme | title = Definition of LYSOZYME|last = | first = | authorlink = | date = | website = Merriam-Webster Medical Dictionary|language=en|archive-url=|archive-date=|url-status=|access-date=2021-02-12}}</ref> Lysozyme is found in certain types of white blood cells ([[neutrophil]]s and [[macrophage]]s.<ref name="Trabers">{{Cite web|url=https://www.tabers.com/tabersonline/view/Tabers-Dictionary/752049/all/urinary_lysozyme?refer=true | title = lysozyme|last = | first = | authorlink = | date = | website = Taber's Medical Dictionary|language=en|archive-url=|archive-date=|url-status=|access-date=2021-02-12}}</ref> ==Function == Lysozyme helps block or restrict the growth of [[bacteria]] by damaging their cell walls.<ref name="Trabers" /> ==ME/CFS== Maes et al. (2012) found that levels of lysozyme and [[neopterin]] were significantly higher in patients with [[ME/CFS]] compared to patients with [[chronic fatigue]] and healthy controls.<ref name=Maes2012 /> ==Notable studies == *2012, Evidence for [[inflammation]] and activation of cell-mediated immunity in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)]]: increased [[Interleukin 1|interleukin-1]], [[TNF-alpha|tumor necrosis factor-Ξ±]], PMN-elastase, lysozyme and neopterin.<ref name=Maes2012>{{Cite journal | last = Maes | first = Michael | authorlink = Michael Maes | last2 = Twisk | first2 = Frank N.M. | authorlink2 = Frank Twisk | authorlink3 = Marta Kubera | last3 = Kubera | first3 = Marta | last4 = Ringel | first4 = Karl | date = Feb 2012 | title = Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-Ξ±, PMN-elastase, lysozyme and neopterin | url =http://linkinghub.elsevier.com/retrieve/pii/S0165032711005301|journal=Journal of Affective Disorders|volume=136|issue=3 | pages = 933β939|doi=10.1016/j.jad.2011.09.004|issn=0165-0327|via=}}</ref> - [[pubmed:21975140|(Abstract)]] * 2021, The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups<ref name="Maes2021">{{Cite journal | last = Maes | first = Michael | authorlink = Michael Maes | last2 = Kubera | first2 = Marta | authorlink2 = | last3 = Stoyanova | first3 = Kristina | authorlink3 = | last4 = Leunis | first4 = Jean-Claude | authorlink4 = | date = 2021-01-29 | title = The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups|url=https://www.preprints.org/manuscript/202101.0623/v1|journal=Preprints|language=en|volume=|issue=|pages=|doi=10.20944/preprints202101.0623.v1|pmc=|pmid=|access-date=Feb 12, 2021|quote=|via=}}</ref> - [https://www.researchgate.net/publication/348868130_The_reification_of_the_clinical_diagnosis_of_myalgic_encephalomyelitis_chronic_fatigue_syndrome_MECFS_as_an_immune_and_oxidative_stress_disorder_construction_of_a_data-_driven_nomothethic_network_and_ (Full text)] ==See also== * [[Neopterin]] * [[Oxidative and nitrosative pathway]] (O&NS) * [[Innate immune system]] ==Learn more == *[https://www.sciencedirect.com/science/article/pii/B9780123749840008937 Lysozyme - Brenner's Encyclopedia of Genetics] (2013) ==References== {{reflist}} [[Category:Proteins]] [[Category:Enzymes]] [[Category:Immunology]] [[Category:Biochemistry and cell biology]]
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