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'''Electroencephalogram''' or '''EEG''' records surface [[brain]] electrical activity, and '''quantified electroencephalogram''' or '''qEEG''' with LORETA source analysis of the qEEG signal uses complex math to localize brain activity deeper in the brain down to a millisecond time scale.<ref name="Zinn2016"/> It can be thought of as a real-time readout of brain function that lets you see what different areas of the brain are doing.<ref name="Zinn2016"/> ==Theory== ==Evidence== Zinn et al. (2016) reported: <blockquote>Our case study confirmed the pattern of dysregulation in the cortex reviewed in the introduction. Furthermore, since both periods of phase shift/lock durations were found to be significantly shorter, that might contribute to an increased rate of phase reset, also seen in our data. Phase reset deregulation--phase locking periods being too brief and phase reset happening too often—appear to be consistent with the associated lower rate of information processing and reaction times found in the ME and CFS literature. These deregulated states represent the [[brain]] during nonoptimal functioning, rendering it inefficient for most types of information processing functioning, whether it is executive functioning, [[Memory problems|memory]], perceptual reasoning or information processing speed. When phase lock is significantly less than normal, as in this data set, the ability of the brain to sustain commitment of resources to mediate different functions is severely compromised. Phase shift duration in this data is also hypoactive, meaning that significantly less neurons are being recruited to perform a function than normal. The results here indicate slowed verbal comprehension, executive functions, perceptual reasoning, processing speed and memory, the sum total of which is known as [[Cognitive dysfunction|cognitive impairment]].<ref name="Zinn2016" /></blockquote> [[File:CLROA-2-110-F1.gif|850px|thumb|center| Figure 1: Results of LORETA current source density in a case with CFS showing widespread decreased current density for delta at 2 Hz and beta (12- 15 Hz) demonstrating a global reduction in brain functioning (blue). The higher frequencies (beta) have been shown to be a function of delta frequencies. In other words, local oscillations are under constant influence of global brain dynamics (Buzsaki, 2006).<ref name="Zinn2016" />]] ==ME/CFS == :[[Brian Vastag]] was able to prove with qEEG and [[Cognitive dysfunction|cognitive]] tests he had "significant problems with [[Visual dysfunction|visual perception]] and analysis, scanning speed, attention, visual motor coordination, motor and mental speed, [[Memory problems|memory]], and [[Word-finding problems|verbal fluency]]" winning his long term disability (LTD) claim.<ref name="Vastag2018"">{{Cite web|url=https://www.meaction.net/2018/06/04/victory-for-me-disability-claim-court-upholds-plaintiffs-lawsuit-after-being-denied-disability/ | title = Victory for ME Disability Claim - U.S. Court Upholds Plaintiff's Lawsuit After Being Denied Disability | last = Tillman | first = Adriane | authorlink= | date = 2018-06-04 | website = #MEAction|language=en-US|archive-url=|archive-date=|url-status=|access-date=2019-02-02}}</ref> ==Cost and availability== ==Notable studies == *2016, [https://sciforschenonline.org/journals/clinical-research/CLROA-2-110.php qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report]<ref name="Zinn2016">{{Cite journal|url=https://www.sciforschenonline.org/journals/clinical-research/CLROA-2-110.php | title = qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report | date = 2016 | last = Zinn | first = ML | author-link = Marcie Zinn | last2 = Zinn | first2 = Mark A. | author-link2 = Mark Zinn | last3 = Jason | first3 = Leonard | author-link3 = Leonard Jason | journal = Clin Res Open Access |pmid=|volume=2|issue=1|pages=|doi=10.16966/2469-6714.110|archive-url=|archive-date=|via=}}</ref> - [https://www.researchgate.net/profile/Leonard-Jason/publication/293049189_qEEG_LORETA_in_Assessment_of_Neurocognitive_Impairment_in_a_Patient_with_Chronic_Fatigue_Syndrome_A_Case_Report/links/56b8f26e08ae39ea9905b6a6/qEEG-LORETA-in-Assessment-of-Neurocognitive-Impairment-in-a-Patient-with-Chronic-Fatigue-Syndrome-A-Case-Report.pdf (Full text)] ==See also== *[[EEG]] *[[Brian Vastag]] *[[Marcie Zinn]] *[[Mark Zinn]] ==Learn more== *[https://en.wikipedia.org/wiki/Quantitative_electroencephalography Wikipedia - Quantitative electroencephalography] *2016, [http://www.meaction.net/2016/02/07/case-study-brain-fog-in-cfs-can-be-seen-in-qeegloreta-analysis/ Case Study: "Brain Fog" in CFS can be seen in qEEG/Loreta] - #MEAction Network *2018, [https://fibromyalgianewstoday.com/2018/03/21/fibromyalgia-cognitive-dysfunction-study-identifies-main-types/ Study Identifies the Types of Cognitive Dysfunction That Are Most Prevalent in Fibromyalgia] *Jun 4, 2018, [https://www.meaction.net/2018/06/04/victory-for-me-disability-claim-court-upholds-plaintiffs-lawsuit-after-being-denied-disability/ Victory For ME Disability Claim – U.S. Court Upholds Plaintiff's Lawsuit After Being Denied Disability] == References == {{Reflist}} [[Category:Medical tests]] [[Category:Neurology]]
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