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Wiskott-Aldrich Syndrome Protein Family Member 3
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'''WASF3''' or '''WAVE3''' or '''Wiskott-Aldrich Syndrome Protein Family Member 3''' is a protein-encoding gene which has been implicated in [[chronic fatigue]] including the fatigue and [[exercise intolerance|exertion intolerance]] found in [[ME/CFS]]. ==Function == WASF3 possibly regulates [[brain]] cytokines involved in the fatigue through the p38 MAPK regulatory pathway.<ref name="genecards">{{Cite web | url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=WASF3 | title = WASF3 Gene - WASP Family Member 3 | website = Genecards | access-date = August 15, 2023}}</ref> ==ME/CFS== In 2023, a [[Centers for Disease Control]] study by Wang et al. reported that over-expression of WASF3 may contribute to exercise intolerance in patients with ME/CFS.<ref name="Wang2023" /> ==Notable studies == *2023, WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome<ref name="Wang2023">{{Cite journal|title=WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome|date=2023-08-22|url=https://pnas.org/doi/10.1073/pnas.2302738120|journal=Proceedings of the National Academy of Sciences|volume=120|issue=34|pages=e2302738120|last=Wang|first=Ping-Yuan|last2=Ma|first2=Jin|last3=Kim|first3=Young-Chae|last4=Son|first4=Annie Y.|last5=Syed|first5=Abu Mohammad|last6=Liu|first6=Chengyu|last7=Mori|first7=Mateus P.|last8=Huffstutler|first8=Rebecca D.|last9=Stolinski|first9=JoEllyn L.|last10=Talagala|first10=S. Lalith|last11=Kang|first11=Ju-Gyeong|language=en|doi=10.1073/pnas.2302738120|issn=0027-8424}}</ref> - [https://www.pnas.org/doi/10.1073/pnas.2302738120 (Abstract)] *2011, Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data<ref name="Pihur2011">{{Cite journal|title=Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data|date=2011-04-22|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089886/|journal=Bioinformation|volume=6|issue=3|pages=120β124|last=Pihur|first=Vasyl|last2=Datta|first2=Somnath|last3=Datta|first3=Susmita|pmc=3089886|pmid=21584188|issn=0973-2063}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089886/#fn-group-1title (Full text)] ==News and articles == * [https://www.science.org/content/article/protein-disrupts-cells-energy-centers-may-be-culprit-chronic-fatigue-syndrome?fbclid=IwAR3l6y8l0siDc8lWWLj8CbmrTD_P1ruMkIY4uZS8Kvv690QplWKS6gX6AVg A protein that disrupts cellsβ energy centers may be a culprit in chronic fatigue syndrome] - Science ==See also== * [[Mitochondria dysfunction]] * [[Genetics of chronic fatigue syndrome]] ==Learn more== * [https://www.genecards.org/cgi-bin/carddisp.pl?gene=WASF3 WASF3 - Genecards] ==References== {{reflist}} [[Category:Proteins]] [[Category:Genes]] [[Category:Mitochondria]] [[Category:Biochemistry and cell biology]]
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