Vitamin D receptor: Difference between revisions
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VDR may be required for the normal development of [[natural killer T cell]]s that react to cells expressing [[CD1d]], as in cells infected by certain viruses.<ref>http://www.pnas.org/content/105/13/5207.short</ref> | VDR may be required for the normal development of [[natural killer T cell]]s that react to cells expressing [[CD1d]], as in cells infected by certain viruses.<ref>http://www.pnas.org/content/105/13/5207.short</ref> | ||
An [[Epstein | An [[Epstein-Barr virus]] protein EBNA-3 has an affinity for [[VDR]] and may actually block the activation of VDR-dependent genes by [[Vitamin D]].<ref>http://www.ncbi.nlm.nih.gov/pubmed/20593215</ref> | ||
Revision as of 03:23, May 2, 2019
The Vitamin D receptor (VDR) is a cell receptor that turns on the expression of certain pathways when activated by Vitamin D.
Individuals who are heterozygous or homozygous for the VDR mutation have lower Vitamin D levels, make less dopamine, and are more tolerant of methyl donors.
VDR may be required for the normal development of natural killer T cells that react to cells expressing CD1d, as in cells infected by certain viruses.[1]
An Epstein-Barr virus protein EBNA-3 has an affinity for VDR and may actually block the activation of VDR-dependent genes by Vitamin D.[2]
