Extracellular matrix

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In biology, the extracellular matrix (ECM) is a three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support of surrounding cells.[1][2][3]

Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.[4]

See also[edit | edit source]

References[edit | edit source]

  1. Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK (February 2016). "Extracellular matrix structure". Advanced Drug Delivery Reviews. 97: 4–27. doi:10.1016/j.addr.2015.11.001. PMID 26562801. 
  2. Bonnans C, Chou J, Werb Z (December 2014). "Remodelling the extracellular matrix in development and disease". Nature Reviews. Molecular Cell Biology. 15 (12): 786–801. doi:10.1038/nrm3904. PMC 4316204Freely accessible. PMID 25415508. 
  3. Michel G, Tonon T, Scornet D, Cock JM, Kloareg B (October 2010). "The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes". The New Phytologist. 188 (1): 82–97. doi:10.1111/j.1469-8137.2010.03374.x. PMID 20618907. open access
  4. Abedin M, King N (December 2010). "Diverse evolutionary paths to cell adhesion". Trends in Cell Biology. 20 (12): 734–42. doi:10.1016/j.tcb.2010.08.002. PMC 2991404Freely accessible. PMID 20817460. 

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.