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Isoleucine (Ile) or L-isoleucine or L-iso-leucine is one of the nine essential amino acids for humans,[1] and is also available in branched chain amino acid (BCAA) supplements.[2]

Purpose[edit | edit source]

Isoleucine is essential for forming hemoglobin, regulating blood sugar levels and energy levels, it also helps with wound healing, removal of nitrogenous wastes, stimulates the immune system, and helps with secreting several hormones.[3]

Isoleucine is a saccharomyces cerevisiae (yeast) metabolite and an E. coli (bacteria) metabolite.[1]

Isoleucine is concentrated in muscle tissues in humans, and like other BCAAs it is mostly oxidized in skeletal muscles rather than the liver.[3][2]

Isoleucine, once catalyzed, contributes to ATP production, which is vital when moving from rest to exercise.[2]

Sources[edit | edit source]

Dietary sources of isoleucine include meats, fish, cheese, eggs, most seeds, and nuts.[1]

Evidence[edit | edit source]

ME/CFS[edit | edit source]

Costs and availability[edit | edit source]

Available over the counter.

Branch-Chain Amino Acids[edit | edit source]

Isoleucine is branched chain amino acid (BCAA) and found in BCAA supplements, along with leucine and valine.[2]

AXA1125[edit | edit source]

Isoleucine is one of a number of amino acids in AXA1125, which is undergoing clinical trials for a number of uses.

Risks and safety[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 PubChem. "Isoleucine". Retrieved October 31, 2021.
  2. 2.0 2.1 2.2 2.3 van der Poll, MCG; Luiking, YC; Dejong, CHC; Soeters, PB (September 2, 2009). "Amino Acids". In Caballero, Benjamin (ed.). Guide to Nutritional Supplements. Oxford, UK: Academic Press. pp. 7–8. ISBN 978-0-12-375661-9.
  3. 3.0 3.1 "Isoleucine | NCI Thesaurus". National Cancer Institute. Retrieved November 1, 2021.