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Osteoporosis, a condition where bones thin and weaken, usually in older adults, resulting in increase risk of bone fractures, especially stress fractures. The risk of developing osteoporosis is considered higher in people with ME/CFS.[1]

A study in 2014, showed that patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort. The researches concluded that although the cause remains unclear, CFS-related fracture might not be associated with osteoporosis.[2]

Presentation[edit | edit source]

Fractures and their causative and repair mechanisms have been topics subject to various forms of investigation for several decades.

Osteoporosis in ME/CFS[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of signaling pathways. Therefore, it is suggested that vitamin C improves bone regeneration.[citation needed]

Notable studies[edit | edit source]

  • 2014, Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study[2] - (Full text)
  • 2019, Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways[citation needed]
  • 2019, Will the Elderly Benefit from a Fruit and Vegetable Nutritional Program? The Case of Vitamin C and Bone Health[citation needed]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Chronic Fatigue Syndrome and Osteoporosis". The Optimum Health Clinic. Jul 14, 2009. Retrieved Oct 10, 2019. 
  2. 2.02.1 Kao, C.-H.; Kuo, C.-N.; Chen, H.-J.; Yang, T.-Y.; Lin, W.-M.; Chen, C.-S. (Aug 1, 2014). "Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study". QJM: An International Journal of Medicine. 107 (8): 635–641. doi:10.1093/qjmed/hcu037. ISSN 1460-2725. 

stress fracture - A tiny crack in a bone caused by repetitive forces such as running or by normal use of a bone that's weakened by a condition such as osteoporosis.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.