Wiskott-Aldrich Syndrome Protein Family Member 3

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WASF3 or WAVE3 or Wiskott-Aldrich Syndrome Protein Family Member 3 is a protein-encoding gene which has been implicated in chronic fatigue including the fatigue and exertion intolerance found in ME/CFS.

Function[edit | edit source]

WASF3 possibly regulates brain cytokines involved in the fatigue through the p38 MAPK regulatory pathway.[1]

ME/CFS[edit | edit source]

In 2023, a Centers for Disease Control study by Wang et al. reported that over-expression of WASF3 may contribute to exercise intolerance in patients with ME/CFS.[2]

Notable studies[edit | edit source]

  • 2023, WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome[2] - (Abstract)
  • 2011, Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data[3] - (Full text)

News and articles[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "WASF3 Gene - WASP Family Member 3". Genecards. Retrieved August 15, 2023.
  2. ↑ 2.0 2.1 Wang, Ping-Yuan; Ma, Jin; Kim, Young-Chae; Son, Annie Y.; Syed, Abu Mohammad; Liu, Chengyu; Mori, Mateus P.; Huffstutler, Rebecca D.; Stolinski, JoEllyn L.; Talagala, S. Lalith; Kang, Ju-Gyeong (August 22, 2023). "WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 120 (34): e2302738120. doi:10.1073/pnas.2302738120. ISSN 0027-8424.
  3. ↑ Pihur, Vasyl; Datta, Somnath; Datta, Susmita (April 22, 2011). "Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data". Bioinformation. 6 (3): 120–124. ISSN 0973-2063. PMC 3089886. PMID 21584188.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

single nucleotide polymorphism (SNP) - A single nucleotide polymorphism (SNP, pronounced "snip") is a potential genetic mutation that occurs in a single spot in the human genome; a difference in a single DNA building block. SNPs are often represented by an "rs" number, such as "rs53576".

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