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Fibromyalgia
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===Immune system research=== Dr. [[Jarred Younger]] believes an overactive [[immune system]] is the cause and will be conducting a study to test this hypothesis.<ref>{{Cite news |url =http://nationalpainreport.com/new-uab-study-could-radically-change-fibromyalgia-treatment-as-we-know-it-8833437.html | title = New UAB Study Could Radically Change Fibromyalgia Treatment As We Know It | last = Gregory Burch | first = Donna | date = 2017-04-24|work=National Pain Report|access-date=2018-08-09|archive-url=|archive-date=|language=en-US}}</ref><ref>{{Cite web | url = https://www.youtube.com/watch?v=8e5xKX036bE | title = Testing the fibromyalgia immune system with lipopolysaccharide (LPS) | last = Younger | first = Jarred | authorlink = Jarred Younger | date = May 24, 2017 | website = YouTube | archive-url=|archive-date=|access-date=|via=Younger Lab}}</ref> An overactive immune system can cause [[inflammation]] and [[chronic pain]].<ref>{{Cite news |url =https://www.epainassist.com/autoimmune/what-is-overactive-immune-system | title = What is Overactive Immune System {{!}} Causes {{!}} Symptoms {{!}} Treatment | last = Kerkar | first = Pramod | date = 2016-09-29|work=ePainAssist|access-date=2018-10-04|archive-url=|archive-date=|language=en-gb}}</ref><ref>{{Cite news |url =https://www.webmd.com/a-to-z-guides/autoimmune-diseases | title = Autoimmune Diseases|work=WebMD|access-date=2018-10-04|language=en-US}}</ref> Dr. William Pridgen's research of [[Herpes simplex virus#HSV-1|HSV-1]] (cold sore virus) as being involved in FM has conducted a successful Phase III clinical trial, which had been fast-tracked by the [[Food and Drug Administration]] (FDA), of a combination drug that suppresses this virus and also helps with pain. {{See also|Fibromyalgia drugs|Fibromyalgia drugs (see drug trials section for IMC-1)}} Recognizing FM may involve activation of the [[immune system]] researchers performed [[Whole exome sequencing|exome sequencing]] on [[chemokine]] genes in a region of chromosome 17 identified in a genome-wide family association study. Their conclusion: "SNPs with significant TDTs were found in 36% of the cohort for [[CCL11]] and 12% for [[MEFV]], along with a protein variant in CCL4 (41%) that affects CCR5 down-regulation, supporting an immune involvement for FM."<ref name="Zhang2018">{{Cite journal | last = Zhang | first = Zhifang | last2 = Feng | first2 = Jinong | last3 = Mao | first3 = Allen | last4 = Le | first4 = Keith | last5 = Placa | first5 = Deirdre La | last6 = Wu | first6 = Xiwei | last7 = Longmate | first7 = Jeffrey | last8 = Marek | first8 = Claudia | last9 = Amand | first9 = R. Paul St | date = 2018-06-21 | title = SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study| url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198625|journal=PLOS ONE|language=en|volume=13|issue=6| pages = e0198625|doi=10.1371/journal.pone.0198625|issn=1932-6203|pmid=29927949|via=}}</ref> Dr David Andersson from the Institute of Psychiatry, Psychology and Neuroscience at King's College London, led a new study into Fibromyalgia being an immune system disorder.<ref name="Goebel2021">{{Cite journal | last = Goebel | first = Andreas | last2 = Krock | first2 = Emerson | last3 = Gentry | first3 = Clive | last4 = Israel | first4 = Mathilde R. | last5 = Jurczak | first5 = Alexandra | last6 = Urbina | first6 = Carlos Morado | last7 = Sandor | first7 = Katalin | last8 = Vastani | first8 = Nisha | last9 = Maurer | first9 = Margot | date = 2021-07-07 | title = Passive transfer of fibromyalgia symptoms from patients to mice | url =https://www.jci.org/articles/view/144201?key=51bf6d85e305f6b62f87#SEC4|journal=The Journal of Clinical Investigation|language=en|volume=131|issue=13|doi=10.1172/JCI144201|issn=0021-9738}}</ref><blockquote>Andersson and his colleagues harvested blood from 44 people with fibromyalgia and injected purified antibodies from each of them into different mice. The mice rapidly became more sensitive to pressure and cold, and displayed reduced grip strength in their paws. Animals injected with antibodies from healthy people were unaffected.<ref name="Guardian2021">{{Cite web | url = http://www.theguardian.com/society/2021/jul/01/fibromyalgia-may-be-a-condition-of-the-immune-system-not-the-brain-study | title = Fibromyalgia may be a condition of the immune system not the brain – study | date = 2021-07-01 | website = The Guardian|language=en|access-date=2021-07-08}}</ref></blockquote><blockquote>Prof Camilla Svensson from the Karolinska Institute in Sweden, who was also involved in the study, said: “Antibodies from people with fibromyalgia living in two different countries, the UK and Sweden, gave similar results, which adds enormous strength to our findings.”<ref name="Guardian2021" /></blockquote>
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