From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

ANS REWIRE is a self-help brain retraining programme created by Dan Neuffer, who states that he used it to recover from ME/CFS. ANS REWIRE is described in Dan Neuffer's book CFS Unravelled.[1][2][3]


ANS REWIRE is a mind-body treatment that is based on the hypothesis that ME/CFS is caused by a malfunctioning amygdala.[1]


No clinical trials have been conducted on ANS REWIRE.

Creator Dan Neuffer promotes ANS REWIRE using anecdotal accounts of those who have seen improvements after using his program.[3]


Risks and safety

There are no clinical trials on ANS REWIRE, so its risks and safety are unknown.

Cost and availability

See also

Learn more


  1. 1.0 1.1 "CFS Unravelled". December 4, 2023. Retrieved January 21, 2024.
  2. "ANS REWIRE". Retrieved January 21, 2024.
  3. 3.0 3.1 "Dan Neuffer on Recovery From ME/CFS and FM Pt. 3: Who Can Recover?". December 4, 2023. Retrieved January 21, 2024.