From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Gamma aminobutyric acid (GABA), is a neurotransmitter made from the amino acid glutamate. GABA is the chief inhibiting, or calming neurotransmitter in the brain, functioning as a brake on the neural circuitry during stress. Low GABA levels are associated with restlessness, anxiety, insomnia and a low mood/depression. GABA works to balance glutamate (excitatory) in the brain. GABA is the brake pedal on a car while glutamate is the gas pedal.[citation needed]

Supplements to support GABA and glutamate are:

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Kendell, Steven F.; Krystal, John H.; Sanacora, Gerrard (February 2005). "GABA and glutamate systems as therapeutic targets in depression and mood disorders". Expert Opinion on Therapeutic Targets. 9 (1): 153–168. doi:10.1517/14728222.9.1.153. ISSN 1744-7631. PMID 15757488.
  2. Kugaya, Akira; Sanacora, Gerard (October 2005). "Beyond monoamines: glutamatergic function in mood disorders". CNS spectrums. 10 (10): 808–819. doi:10.1017/s1092852900010403. ISSN 1092-8529. PMID 16400244.
  3. Abdou, Adham M.; Higashiguchi, S.; Horie, K.; Kim, Mujo; Hatta, H.; Yokogoshi, H. (2006). "Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans". BioFactors (Oxford, England). 26 (3): 201–208. doi:10.1002/biof.5520260305. ISSN 0951-6433. PMID 16971751.