Central nervous system

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Central nervous system diagram, showing brain attached to the spinal cord
Central Nervous System[1]

The central nervous system (CNS) is made up of the brain and the spinal cord.[2]

The brain and spinal cord have their own immune system.[3] Microglia cells are a part of that immune system.[4]

Injury to the brain or spinal cord, such as those caused by stroke or trauma, result in a considerable weakening of the immune system.[5]  

Disease involvement in ME/CFS[edit | edit source]

Autopsy[edit | edit source]

ME/CFS patient autopsies have shown changes to the spinal cord.

Brain imaging[edit | edit source]

Cytokines[edit | edit source]

Cytokines, found in spinal fluid, are increasingly found to be altered in ME/CFS patients and there are several studies by Ian Lipkin and Mady Hornig with the Microbe Discovery Project. See: Cytokine (Chronic Fatigue Syndrome section)

Neuropathological findings[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Image: Central nervous system Facts for Kids". kids.kiddle.co. Retrieved September 29, 2018.
  2. "Overview of the Nervous System - Brain, Spinal Cord, and Nerve Disorders - MSD Manual Consumer Version". MSD Manual Consumer Version. Retrieved September 29, 2018.
  3. "Scientists create new map of brain's immune system". ScienceDaily. February 19, 2019. Retrieved March 31, 2019.
  4. "Brain immune system is key to recovery from motor neuron degeneration: Results in study point to new approaches for ALS therapy". ScienceDaily. February 20, 2018. Retrieved March 31, 2019.
  5. "An interconnection between the nervous and immune system: Neuroendocrine reflex triggers infections". ScienceDaily. September 29, 2017. Retrieved March 31, 2019.
  6. "The Story of Sophia and M.E." Invest in ME Research. Retrieved August 10, 2018.
  7. "Neuropathological Report". sophiaandme.org.uk. Retrieved August 10, 2018.
  8. Speedy, Dr (April 16, 2011). "THE NICEGUIDELINES BLOG: Lynn Gilderdale's autopsy showed 'dorsal root ganglionitis' - infected nerve roots, just like Sophia Mirza's". THE NICEGUIDELINES BLOG. Retrieved August 16, 2018.
  9. Gilderdale, Kay (April 14, 2011). One Last Goodbye: Sometimes only a mother's love can help end the pain. Ebury Press. ISBN 9780091939144.
  10. "talkhealth forums - dorsal root ganglionitis". talkhealthpartnership.com. Retrieved August 16, 2018.
  11. Tillman, Adriane (May 19, 2018). "Inquest Rules Merryn Crofts Died Due to Severe ME | #MEAction". The MEAction Network. Retrieved August 16, 2018.
  12. Ferrero, Kimberly; Silver, Mitchell; Cocchetto, Alan; Masliah, Eliezer; Langford, Dianne (April 5, 2017). "CNS findings in chronic fatigue syndrome and a neuropathological case report". Journal of Investigative Medicine: jim–2016–000390. doi:10.1136/jim-2016-000390. ISSN 1081-5589. PMID 28386034.
  13. "2-Minute Neuroscience: Divisions of the Nervous System". YouTube. Neuroscientifically Challenged. August 8, 2014.
  14. "Central Nervous System". blausen.com. November 25, 2015. Retrieved August 16, 2018.