[Close]
This page was created by volunteers like you!
Help us make it even better. To learn more about contributing to MEpedia, click here.
Join the movement
Visit #MEAction to find support or take action. Donate today to help us improve and expand this project.
Congratulations!
MEpedia has got over 30 million views as of August 2022!

Indoleamine-2,3-dioxygenase

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Indoleamine-2,3-dioxygenase or indolamine-2,3-dioxygenase or IDO is an enzyme involved in the human body's metabolism of the essential amino acid tryptophan.[1][2]

The IDO enzyme degrades (converts) tryptophan into kynurenine, and this process is strongly linked to the IDO1 and IDO2 genes.[1][3]

Notable studies and publications[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ Jump up to: 1.0 1.1 Bilir, Cemil; Sarisozen, Can (July 1, 2017). "Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller?". Journal of Oncological Sciences. 3 (2): 52–56. doi:10.1016/j.jons.2017.04.001. ISSN 2452-3364.
  2. ↑ Jump up to: 2.0 2.1 Phair, RobertD.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.
  3. ↑ National Center for Biotechnology Information (March 22, 2020). "IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved May 1, 2020.
  4. ↑ https://doi.org/10.3892/mmr.2018.8537

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

metabolic trap hypothesis An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.

etiology The cause of origin, especially of a disease.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

Retrieved from "https://me-pedia.org/w/index.php?title=Indoleamine-2,3-dioxygenase&oldid=237525"