Interleukin 6

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Notable studies[edit | edit source]

  • 1998, Interleukin-6 and Disease: Two Case Reports that Point to the Usefulness of Measuring Cytokine Levels in Clinical Settings
    Abstract - "Chronic fatigue syndrome has been associated with patterns of cytokine imbalances whose relevance to disease status remains to be documented. We present here two case reports that illustrate the relevance of measuring intcrlcuk.in-6 levels in biological fluids in two clinical entities: hypothermia and Sjögren's syndrome. Further studies of this nature in extended patient populations will allow to discern the relevant contribution among the pleiotropy of roles of each particular cytokine in different clinical settings. It becomes apparent from the cases presented that the clinical manifestation of the imbalance in the expression of a particular cytokine is contingent upon the compartment where it occurs and upon levels of other cylokines. Similar studies will allow to define signature cytokine imbalances for each disease condition and may also shed light on thus far uncharacterized etiological agents."[1]
  • 2002 : During acute influenza-like symptoms in 19 CFS patients and 10 normal controls an IL-6 challenge was administered: CFS somatic symptoms increased more rapidly in CFS patients compared with controls - cognitive impairment was not affected during the IL-6 challenge.[2]
These findings may serve as a robust biomarker:
* IL-1α, higher in recently ill adolescent ME/CFS subjects, was progressively less important with duration.
* IL-6, lower in early illness, higher for subjects ill for more than 2 years and over 18 years of age.
* IL-8, higher in the recently afflicted, lower for subjects ill for more than 2 years.


Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Roberto Patarca & Mary Ann Fletcher. (1998). Interleukin-6 and Disease: Two Case Reports that Point to the Usefulness of Measuring Cytokine Levels in Clinical Settings. Journal of Chronic Fatigue Syndrome', Vol. 4, Iss. 1, pp. 53-69. http://dx.doi.org/10.1300/J092v04n01_07
  2. Psychol Med. 2002 Aug;32(6):1075-89. Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome. Arnold MC1, Papanicolaou DA, O'Grady JA, Lotsikas A, Dale JK, Straus SE, Grafman J. https://www.ncbi.nlm.nih.gov/pubmed/12214788
  3. Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth; Katz, Ben; Klimas, Nancy; Fletcher, Mary Ann (Mar 10, 2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, (2016) 17 (13), doi:10.1186/s12865-016-0142-3, PMID 26965484 

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.