Nancy Klimas

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Nancy G. Klimas, MD, is an American researcher and physician who is the Director at the Institute for Neuro Immune Medicine at Nova Southeastern University in Miami and Ft. Lauderdale, Florida. She is, also: Director of Clinical Immunology Research, Miami VAMC; Professor of Medicine, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; Chair, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; and Professor Emerita, University of Miami, School of Medicine.[1]

Awards[edit | edit source]

  • 2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by IACFS/ME[2]
  • 2014, Rudy Perpich Senior Lectureship Award, presented to a distinguished CFS/FMS scientist, physician or healthcare worker awarded by IACFS/ME.[2]

Committees[edit | edit source]

2015 Institute of Medicine report[edit | edit source]

Dr. Klimas was one of the ME/CFS experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened to produce the 2015 Institute of Medicine report.[3]

Case definition authorships[edit | edit source]

Klimas is one of the authors of the 2011 case definition, International Consensus Criteria,[4] the 2006 Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome[5], as well as, one of the authors of the 2003 Canadian Consensus Criteria for ME/CFS, published as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:Clinical Working Case Definition,Diagnostic and Treatment Protocols[6]

Chronic Fatigue Syndrome Advisory Committee[edit | edit source]

Dr. Klimas served as a voting member of the Chronic Fatigue Syndrome Advisory Committee for the U.S. Department of Health and Human Services from April 1, 2007 to April 1, 2011.[7]

International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[edit | edit source]

Dr. Klimas served as past President of the Board of Directors of the International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME) from 2004-2009.[8] She has been awarded the IACFS/ME Nelson Gantz Outstanding Clinician Award (in 2011) and the IACFS/ME Rudy Perpich Senior Lectureship Award (in 2014).[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Co-chair of the Immune Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention.[9]

ME/CFS Gene Study[edit | edit source]

Nancy Klimas is part of the Institute for Neuroimmune Medicine's ME/CFS Gene Study, which aims to "create a one of a kind genetic database for ME/CFS."[10] The ME/CFS Gene Study is a worldwide internet-based study that asks for either people with ME/CFS or Healthy Controls to submit gene information they have acquired themselves. Participants answer a questionnaire to check they can take part, then arrange their own gene testing through 23andMe or Ancestry DNA, which need saliva samples to be sent by post. They then send the results electronically to the study group.[10]

Research studies[edit | edit source]

Earlier studies[edit | edit source]

For earlier studies: Research studies of Nancy Klimas

Recent studies[edit | edit source]

Talks and interviews[edit | edit source]

There are many videos on YouTube of Nancy Klimas speaking about her work.[29]

Quotations[edit | edit source]

  • "They experience a level of disability equal to that of patients with late-stage AIDS and patients undergoing chemotherapy"[31]
  • "I split my clinical time between the two illnesses, and I can tell you if I had to choose between the two illnesses (in 2009) I would rather have H.I.V."[32]

Advocacy[edit | edit source]

Open Letter to The Lancet[edit | edit source]

Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Klimas, along with 41 colleagues in the ME/CFS field, signed the second letter.

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. http://www.nova.edu/nim/clinic/dr.-nancy-klimas-bio-page.html
  2. 2.02.12.2 IACFS/ME. "Former IACFS/ME Awardees". 
  3. Clayton, Ellen Wright; Alegria, Margarita; Bateman, Lucinda; Chu, Lily; Cleeland, Charles; Davis, Ronald; Diamond, Betty; Ganiats, Theodore; Keller, Betsy; Klimas, Nancy; Lerner, A Martin; Mulrow, Cynthia; Natelson, Benjamin; Rowe, Peter; Shelanski, Michael (2015). "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness" (PDF). nationacademies.org. 
  4. Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (Aug 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890Freely accessible. PMID 21777306. 
  5. Jason, Leonard A; Jordan, Karen; Miike, Teruhisa; Bell, David S; Lapp, Charles; Torres-Harding, Susan; Rowe, Kathy; Gurwitt, Alan; De Meirleir, Kenny; Van Hoof, Elke LS (2006), "A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 13 (2-3): 1-44, doi:10.1300/J092v13n02_01 
  6. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02 
  7. http://nih.granicus.com/DocumentViewer.php?file=nih_e174f9bd-ae0f-4a45-9955-827cb608db2f.pdf
  8. http://iacfsme.org/Organization/Committees-of-the-IACFS-ME.aspx
  9. https://www.commondataelements.ninds.nih.gov/ReportViewer.aspx?%2fnindscdereports%2fRoster&rs%3aCommand=Render&rc:Parameters=false&diseaseid=MECFS&custom:disableExcel=true&custom:disableXML=true&custom:disableCSV=true
  10. 10.010.1 Nova Southeastern University. "ME/CFS Genes Study | NSU Institute for Neuro Immune Medicine". NSU. Retrieved Nov 1, 2018. 
  11. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Ironson, Gail H.; Wohlgemuth, William; Vera Nunez, Maria; Garcia, Lina; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2016), "Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women", Journal of Neuroimmunology, 0 (0), doi:10.1016/j.jneuroim.2016.12.008 
  12. Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth; Katz, Ben; Klimas, Nancy; Fletcher, Mary Ann (2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, doi:10.1186/s12865-016-0142-3 
  13. Harvey, Jeanna M.; Broderick, Gordon; Bowie, Alanna; Barnes, Zachary M.; Katz, Ben Z.; O’Gorman, Maurice R. G.; Vernon, Suzanne D.; Fletcher, Mary Ann; Klimas, Nancy G. (Apr 26, 2016). "Tracking post-infectious fatigue in clinic using routine Lab tests". BMC Pediatrics. 16. doi:10.1186/s12887-016-0596-8. ISSN 1471-2431. PMC 4847210Freely accessible. PMID 27118537. 
  14. Barkin, JA; Czul, F; Barkin, JS; Klimas, NG; Rey, IR; Moshiree, B (2016), "Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis", Digestive Diseases and Sciences, 61 (8): 2344-50, doi:10.1007/s10620-016-4227-x, PMID 27344315 
  15. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2017), "Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model", Int J Psychophysiol, 0 (0), doi:10.1016/j.ijpsycho.2017.09.009 
  16. Halpin, P; Williams, MV; Klimas, NG; Fletcher, MA; Barnes, Zachary; Ariza, ME (2017), "Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology", Journal of Medical Virology, doi:10.1002/jmv.24810, PMID 28303641 
  17. Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y 
  18. Unger, Elizabeth R.; Lin, Jin-Mann S.; Tian, Hao; Natelson, Benjamin H; Lange, Gudrun; Vu, Diana; Blate, Michelle; Klimas, Nancy G.; Balbin, Elizabeth G.; Bateman, Lucinda; Allen, Ali; Lapp, Charles W.; Springs, Wendy; Kogelnik, Andreas M.; Phan, Catrina C.; Danver, Joan; Podell, Richard N.; Fitzpatrick, Trisha; Peterson, Daniel L.; Gottschalk, C. Gunnar; Rajeevan, Mangalathu S.; MCAM Study Group (2017), "Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study.", American Journal of Epidemiology, 1–10, doi:10.1093/aje/kwx029 
  19. Hall, DL; Lattie, EG; Milrad, SF; Czaja, S; Fletcher, MA; Klimas, N; Perdomo, D; Antoni, MH (2017), "Telephone-administered versus live group cognitive behavioral stress management for adults with CFS", J Psychosom Res, 93: 41-47, doi:10.1016/j.jpsychores.2016.12.004 
  20. Montoya, Jose G; Anderson, Jill N; Adolphs, Danya L; Bateman, Lucinda; Klimas, Nancy; Levine, Susan M; Garvert, Donn W; Kaiser, Jon D (2018), "KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial" (PDF), International Journal of Clinical and Experimental Medicine, 11 (3): 2890-2900 
  21. Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J. R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9 
  22. Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (Jul 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PlosOne. doi:10.1371/journal.pone.0201066. 
  23. Klimas, N.G.; Fletcher, M.A.; Abreu, M.M.; Aenlle, K.; Craddock, T.; Broderick, G. (Feb 2019). "From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story". Brain, Behavior, and Immunity. 76: e40. doi:10.1016/j.bbi.2018.11.301. 
  24. Morris, Matthew C.; Cooney, Katherine E.; Sedghamiz, Hooman; Abreu, Maria; Collado, Fanny; Balbin, Elizabeth G.; Craddock, Travis J.A.; Klimas, Nancy G.; Broderick, Gordon; Fletcher, Mary Ann (Mar 2019). "Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.03.002. 
  25. Richman, Spencer; Morris, Matthew C.; Broderick, Gordon; Craddock, Travis J.A.; Klimas, Nancy G.; Fletcher, Mary Ann (Mar 2019). "Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.02.011. 
  26. Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (Mar 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011. 
  27. Perez, Melanie; Jaundoo, Rajeev; Hilton, Kelly; Del Alamo, Ana; Gemayel, Kristina; Klimas, Nancy G.; Craddock, Travis J.; Nathanson, Lubov (May 2019). "Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. doi:10.3389/fped.2019.00206. 
  28. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Ironson, Gail; Doss, Brian D.; Mendez, Armando; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (Jul 2019). "Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue". Social Science & Medicine: 112392. doi:10.1016/j.socscimed.2019.112392. 
  29. YouTube - nancy klimas
  30. http://www.investinme.eu/iimec12.shtml
  31. University of Miami ME/CFS Researcher Nancy Klimas, MD, Explains Complexity of Chronic Fatigue Syndrome in Terms That Anybody Can Understand
  32. Readers Ask: A Virus Linked to Chronic Fatigue Syndrome

Myalgic encephalomyelitis or chronic fatigue syndrome

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.