Myelin basic protein

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Myelin basic proteins or MBP is a group of seven proteins produced from a single gene, and are found in the central and peripheral nervous system.[1] The gene encoding myelin basic protein is also referred to as MBP.[2]

Function[edit | edit source]

Myelin basic protein (MBP) is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin,[3] and MBP levels in cerebral spinal fluid are considered as a marker of active demyelination.[4][2]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

  • 2023, Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[5] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Achiron, A.; Miron, S. (January 1, 2007). "76 - MYELIN ASSOCIATED ANTIBODIES: MYELIN-ASSOCIATED GLYCOPROTEIN AUTOANTIBODIES, MYELIN BASIC PROTEIN AUTOANTIBODIES AND MYELIN PROTEOLIPID AUTOANTIBODIES IN NEUROLOGIC DISEASES". In Shoenfeld, Yehuda; Gershwin, M. Eric; Meroni, Pier Luigi (eds.). Autoantibodies (Second ed.). Burlington: Elsevier. pp. 619–626. ISBN 978-0-444-52763-9.
  2. ↑ 2.0 2.1 "MBP Gene - Myelin basic protein - Gene card". Gene cards. Retrieved December 31, 2023.
  3. ↑ Boggs, J. M. (September 1, 2006). "Myelin basic protein: a multifunctional protein". Cellular and Molecular Life Sciences CMLS. 63 (17): 1945–1961. doi:10.1007/s00018-006-6094-7. ISSN 1420-9071.
  4. ↑ "CSF myelin basic protein". Medline Plus Medical Encyclopedia. Retrieved December 30, 2023.
  5. ↑ Jensen, Michael Anthony; Dafoe, Miranda Lee; Wilhelmy, Julie; Cervantes, Layla; Okumu, Anna N.; Kipp, Lucas; Nemat-Gorgani, Mohsen; Davis, Ronald Wayne (November 27, 2023). "Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Biochemistry. doi:10.1021/acs.biochem.3c00433. ISSN 1520-4995. PMID 38011893.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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