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NTRK

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Neurotrophic Receptor Tyrosine Kinase or NTRK is a superfamily of receptor tyrosine kinases[1] these are protein-encoding genes that may be linked to myalgic encephalomyelitis/chronic fatigue syndrome.[2]

NTRK1[edit | edit source]

Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.[3]

ME/CFS[edit | edit source]

Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as cognitive disability and sensorial dysfunctions (altered pain sensitivity)44".[2] In this small study of patients with severe ME, NTRK1 levels were found to be significantly higher in the severely ill patients compared to healthy controls.[2]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Thiriet, Marc (December 14, 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. p. 648. ISBN 978-1-4614-1991-4.
  2. ↑ Jump up to: 2.0 2.1 2.2 2.3 Almenar-Pérez, Eloy; Sarría, Leonor; Nathanson, Lubov; Oltra, Elisa (February 7, 2020). "Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Scientific Reports. 10 (1): 1–15. doi:10.1038/s41598-020-58506-5. ISSN 2045-2322. Retrieved February 12, 2020.
  3. ↑ GeneCards. "NTRK1 Gene | NTRK1 Protein | NTRK1 Antibody". genecards.org. Retrieved February 12, 2020.

extracellular vesicle An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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