Dr Nathanson research interests include exploring altered genetic expression in the immune cells of ME/CFS patients and the potential role of DNA methylation, an epigenetic process that can turn genes on or off, in ME/CFS.
2017 Ramsay Award[edit | edit source]
A team comprised of Dr. Elisa Oltra of Universidad Católica de Valencia, Spain, and Drs. Lubov Nathanson, Vladimir Beljanski and Malav Suchin Trivedi of Nova Southeastern University, US, were awarded a 2017 Ramsay Award grant from the Solve ME/CFS Initiative for researching the effect of ME/CFS on epigenetic regulation in specific immune cell types.
ME/CFS Common Data Element (CDE) Project[edit | edit source]
Member of the Baseline/Covariate Working Group, the Neurologic/Cognitive/CNS Imaging Working Group, and the Biomarkers Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention. This working group reviewed data collection instruments widely used by investigators in the ME/CFS field, and either recommended their use unchanged or (more often) proposed some modifications.
Notable studies[edit | edit source]
- 2015, Using gene expression signatures to identify novel treatment strategies in gulf war illness - (Full text)
- 2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns - (Full Text)
- 2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules - (Abstract)
- 2019, Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation - (Full text)
- 2019, Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study - (Abstract)
- 2020, Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - (Full text)
Talks and interviews[edit | edit source]
Online presence[edit | edit source]
Learn more[edit | edit source]
- NSU Research Spotlight: Lubov Nathanson, Ph.D.
- Nova Southeastern University Researchers Receive $800,000 Grant to Research Gulf War Illness
See also[edit | edit source]
References[edit | edit source]
- "NSU Research Spotlight: Lubov Nathanson, Ph.D. | NSU Newsroom". nsunews.nova.edu. Retrieved Apr 9, 2019.
- "2017 Ramsay Award Program Results". Solve ME/CFS Initiative. Retrieved Mar 29, 2019.
- "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019.
- "NINDS CDE Project: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Baseline/Covariate Information Subgroup" (PDF). ninds.nih.gov. Retrieved Mar 4, 2020.
- Craddock, Travis J.A.; Harvey, Jeanna M.; Nathanson, Lubov; Barnes, Zachary M.; Klimas, Nancy G.; Fletcher, Mary Ann; Broderick, Gordon (Jul 9, 2015). "Using gene expression signatures to identify novel treatment strategies in gulf war illness". BMC Medical Genomics. 8. doi:10.1186/s12920-015-0111-3. ISSN 1755-8794. PMC . PMID 26156520.
- Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (Jul 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PlosOne. doi:10.1371/journal.pone.0201066.
- Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (Mar 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011.
- Almenar-Pérez, Eloy; Ovejero, Tamara; Sánchez-Fito, Teresa; Espejo, José A.; Nathanson, Lubov; Oltra, Elisa (Apr 2019). "Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation". Clinical Therapeutics. 41 (4): 675–698. doi:10.1016/j.clinthera.2019.02.012.
- Perez, Melanie; Jaundoo, Rajeev; Hilton, Kelly; Del Alamo, Ana; Gemayel, Kristina; Klimas, Nancy G.; Craddock, Travis J.; Nathanson, Lubov (May 2019). "Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. doi:10.3389/fped.2019.00206.
- Almenar-Pérez, Eloy; Sarría, Leonor; Nathanson, Lubov; Oltra, Elisa (Dec 2020). "Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Scientific Reports. 10 (1): 2064. doi:10.1038/s41598-020-58506-5. ISSN 2045-2322.
cognition - Thought processes, including attention, reasoning, and memory.
central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.
extracellular vesicle - An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)