Autoimmune disease

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Autoimmune diseases arise from an abnormal immune response of the body against substances and tissues normally present in the body.

Types of autoimmune diseases[edit | edit source]

Autoimmune diseases can be localized, which means affecting only specific tissues or organs, or systematic, making affecting many tissues or organs.[1]

Localized autoimmune disease[edit | edit source]

Examples include:

Systemic autoimmune diseases[edit | edit source]

Examples include:

Autoimmune hypothesis in ME and CFS[edit | edit source]

Shows fibromyalgia 30-77% overlap, Hashimoto's thyroiditis 17-20%, POTS 11-40% overlap and family history of autoimmune conditions 18-41% overlap.
Autoimmune conditions in people with ME/CFS. Source: Sotzny et al (2018), EUROMENE project.

Many people with ME/CFS also have autoimmune conditions such as Fibromyalgia or Hashimoto's thyroiditis, or have a family history of autoimmune diseases.[2]POTS, or postural orthostatic tachycardia syndrome, can be initiated or maintained by autoantibodies as well, and POTS is common in people with ME. A number of different immune system abnormalities have been found in some patients with ME/CFS.[2]


ME/CFS is being investigated to determine if it is caused by Autoimmunity in some patients.

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.11.21.3 British Society for Immunology (Mar 2016). "Autoimmunity" (PDF). Retrieved Jul 12, 2019. 
  2. 2.02.12.2 Sotzny, Franziska; Blanco, Julià; Capelli, Enrica; Castro-Marrero, Jesús; Steiner, Sophie; Murovska, Modra; Scheibenbogen, Carmen (2018), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease", Autoimmunity Reviews, 17 (6): 601-609, doi:10.1016/j.autrev.2018.01.009 

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation

Myalgic encephalomyelitis or chronic fatigue syndrome

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.