Jesús Castro-Marrero

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Source:Vall d'Hebron Research Institute (VHIR)

Jesús Castro-Marrero, PhD, (also known as Jesus Castro) works at Cornell ME/CFS Collaborative Research Center, New York, US. His research focuses on Extracellular Vesicles/Exosomes biology and decoding differences in the mRNA and miRNA expression cargo from Extracellular Vesicles (EVs) and blood immune cells (peripheral blood mononuclear cells) before and after a 24 hour CPET challenge in a gender-specific manner in individuals with ME/CFS.

Previously, he was a Senior Research Associate in Biochemistry and Molecular Biology at the Vall d’Hebron University Hospital Research Institute (VHIR), Barcelona, Spain.[1]

EUROMENE[edit | edit source]

Dr. Castro-Marrero is a Working Group Leader on Epidemiology of ME/CFS across Europe on behalf of the EUROMENE, a European Union not-for-profit research organization committed to tackling the cause and treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[2]

Education[edit | edit source]

  • 1987 - B.S. in Biochemistry, School of Biological Sciences, University of Havana, Cuba
  • 1999 - Ph.D. in Biochemistry and Molecular Biology, Valladolid University School of Medicine, Spain

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Vall d'Hebron Research Institute (VHIR)". Retrieved July 15, 2019.
  2. "Action CA15111". COST. Retrieved April 24, 2020.
  3. Curriu, Marta; Carrillo, Jorge; Massanella, Marta; Rigau, Josepa; Alegre, José; Puig, Jordi; Garcia-Quintana, Ana M; Castro-Marrero, Jesús; Negredo, Eugènia; Clotet, Bonaventura; Cabrera, Cecilia; Blanco, Julià (2013), "Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome", Journal of Translational Medicine, 11 (68), doi:10.1186/1479-5876-11-68
  4. Castro-Marrero, J.; Cordero, M.D.; Sáez-Francas, N.; Jimenez-Gutierrez, C.; Aguilar-Montilla, F.J.; Aliste, L.; Alegre-Martin, J. (2013), "Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?", Antioxidants & Redox Signaling, 19 (15): 1855-1860, doi:10.1089/ars.2013.5346, PMID 23600892
  5. Faro, M.; Sáez-Francàs, N.; Castro-Marrero, J.; Aliste, L.; Collado, A.; Alegre, J. (2014), "Impact of the fibromyalgia in the chronic fatigue syndrome", Medicina Clinica (Barc), 142 (12): 519-525, doi:10.1016/j.medcli.2013.06.030, PMID 24387955
  6. Castro-Marrero, J.; Cordero, M.D.; Segundo, M.J.; Sáez-Francàs, N.; Calvo, N.; Román-Malo, L.; Aliste, L.; Fernández de Sevilla, T.; Alegre, J. (2015), "Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome?", Antioxidants & Redox Signaling, 22 (8): 679–685, doi:10.1089/ars.2014.6181, PMID 25386668
  7. Calvo, N.; Sáez-Francas, N.; Valero, S.; Castro-Marrero, J.; Alegre, J.; Casas, M. (2015), "Diagnostic concordance between categorical and dimensional instrument to assess personality in chronic fatigue syndrome: PDQ-4+ and TCI-R", European Journal of Psychological Assessment, 33: 158-165, doi:10.1027/1015-5759/a000281
  8. Sáez-Francàs, Naia; Calvo, Natalia; Alegre, José; Castro-Marrero, Jesús; Casas, Miguel (2015), "Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology", Comprehensive Psychiatry, 62: 13-19, doi:10.1016/j.comppsych.2015.06.010
  9. Faro, Mónica; Sáez-Francàs, Naia; Castro-Marrero, Jesús; Aliste, Luisa; Fernández de Sevilla, Tomás; Alegre, Jose (2015), "Gender Differences in Chronic Fatigue Syndrome", Reumatologia clinica, 12 (2), doi:10.1016/j.reuma.2015.05.007
  10. Scheibenbogen, Carmen; Freitag, Helma; Blanco, Julià; Capelli, Enrica; Lacerda, Eliana; Authier, Jerome; Meeus, Mira; Castro Marrero, Jesus; Nora-Krukle, Zaiga; Oltra, Elisa; Strand, Elin Bolle; Shikova, Evelina; Sekulic, Slobodan; Murovska, Modra (July 26, 2017). "The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE". Journal of Translational Medicine. 15 (1). doi:10.1186/s12967-017-1263-z. ISSN 1479-5876. PMC 5530475. PMID 28747192.
  11. Castro-Marrero, J. (2017), "Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome", British Journal of Pharmacology, 174 (5): 345–369, doi:10.1111/bph.13702, PMID 28052319
  12. Castro-Marrero, J.; Faro, M.; Aliste, L.; Sáez-Francàs, N.; Calvo, N.; Martínez-Martínez, A.; de Sevilla, T.F.; Alegre, J. (2017), "Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study", Psychosomatics, 58 (5): 533 - 543, doi:10.1016/j.psym.2017.04.010
  13. Cambras, T.; Castro-Marrero, J.; Zaragoza, MC.; Díez-Noguera, A.; Alegre, J. (2018), "Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", PLoS ONE, 13 (6): e0198106, doi:10.1371/journal.pone.0198106
  14. Castro-Marrero, Jesús; Zaragozá, Maria Cleofé; González-Garcia, Sergio; Aliste, Luisa; Sáez-Francàs, Naia; Romero, Odile; Ferré, Alex; Fernández de Sevilla, Tomás; Alegre, José (2018), "Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis", J Sleep Res: e12703, doi:10.1111/jsr.12703, PMID 29770505
  15. Sotzny, Franziska; Blanco, Julià; Capelli, Enrica; Castro-Marrero, Jesús; Steiner, Sophie; Murovska, Modra; Scheibenbogen, Carmen (2018), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease", Autoimmunity Reviews, doi:10.1016/j.autrev.2018.01.009
  16. Castro-Marrero, Jesús; Serrano-Pertierra, Esther; Oliveira-Rodríguez, Myriam; Zaragozá, Maria Cleofé; Martínez-Martínez, Alba; Blanco-López, María del Carmen; Alegre, José (2018), "Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study", Journal of Extracellular Vesicles, 7 (1), doi:10.1080/20013078.2018.1453730
  17. Calvo, Natalia; Pueyo, Natalia; Gutiérrez, Fernando; Ferrer, Marc; Castro-Marrero, Jesús; Alegre, José; Casas, Miquel; Ramos Quiroga, Josep-Antoni; Sáez-Francàs, Naia (July 2018). "Dimensional Personality Assessment among a Chronic Fatigue Syndrome (CFS) sample with Personality Inventory for DSM-5 (PID-5)". Actas Espanolas De Psiquiatria. 46 (4): 125–132. ISSN 1578-2735. PMID 30079926.
  18. Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (September 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183.
  19. Castro-Marrero, Jesús; Zaragozá, Maria Cleofé; Domingo, Joan Carles; Martinez-Martinez, Alba; Alegre, José; von Schacky, Clemens (December 2018). "Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis". Prostaglandins, Leukotrienes and Essential Fatty Acids. 139: 20–24. doi:10.1016/j.plefa.2018.11.006. ISSN 0952-3278.
  20. Castro-Marrero, Jesús; Faro, Mónica; Zaragozá, María Cleofé; Aliste, Luisa; de Sevilla, Tomás Fernández; Alegre, José (December 2019). "Unemployment and work disability in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a community-based cross-sectional study from Spain". BMC Public Health. 19 (1). doi:10.1186/s12889-019-7225-z. ISSN 1471-2458. PMC 6599355. PMID 31253111.
  21. Escorihuela, Rosa María; Capdevila, Lluís; Castro, Juan Ramos; Zaragozà, María Cleofé; Maurel, Sara; Alegre, José; Castro-Marrero, Jesús (December 2020). "Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis". Journal of Translational Medicine. 18 (1): 4. doi:10.1186/s12967-019-02184-z. ISSN 1479-5876. PMC 6943898. PMID 31906988.
  22. Cheema, Amanpreet K.; Sarria, Leonor; Bekheit, Mina; Collado, Fanny; Almenar‐Pérez, Eloy; Martín‐Martínez, Eva; Alegre, Jose; Castro‐Marrero, Jesus; Fletcher, Mary A.; Klimas, Nancy; Oltra, Elisa; Nathanson, Lubov (April 14, 2020). "Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS". Journal of Cellular and Molecular Medicine. 00: 1–13. doi:10.1111/jcmm.15260. ISSN 1582-4934. PMID 32291908.
  23. Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557.
  24. Giloteaux, Ludovic; O'Neal, Adam; Castro-Marrero, Jesús; Levine, Susan M.; Hanson, Maureen R. (December 2020). "Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study". Journal of Translational Medicine. 18 (1): 387. doi:10.1186/s12967-020-02560-0. ISSN 1479-5876. PMC 7552484.
  25. Malato, João; Sotzny, Franziska; Bauer, Sandra; Freitag, Helma; Fonseca, André; Grabowska, Anna D; Graça, Luís; Cordeiro, Clara; Nacul, Luís; Lacerda, Eliana M; Castro-Marrero, Jesus; Scheibenbogen, Carmen; Westermeier, Francisco; Sepúlveda, Nuno (March 24, 2021). "The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies". medRxiv. doi:10.1101/2021.03.23.21254175. PMID 33791744.