Theory[edit | edit source]
The Open Medicine Foundation, with immunologist Mark Davis, and geneticist Lars Steinmetz, is currently investigating the replication of T cells in ME, which may indicate an autoimmune disease is present in some ME/CFS patients.
Evidence[edit | edit source]
Evidence for autoimmunity in ME and CFS[edit | edit source]
Many people with ME/CFS also have autoimmune conditions such as Fibromyalgia or Hashimoto's thyroiditis, or have a family history of autoimmune diseases.POTS, or postural orthostatic tachycardia syndrome, can be initiated or maintained by autoantibodies as well, and POTS is common in people with ME. A number of different immune system abnormalities have been found in some patients with ME/CFS.
Samples from a large cohort (n=268) in Berlin, Germany and a smaller sample of patients treated with Rituximab (n=25) were measured against controls (n=168). Researchers found that antibodies against a neurotransmitter receptor were elevated in 29.5% of patients. Specifically, antibodies to ß2 adrenergic and M3 and M4 muscarinic cholinergic receptors, which are both G protein-coupled receptors (GCPRs). In patients receiving Rituximab, those who were responders had significantly lower levels of ß2 and M4 autoantibodies after treatment. The authors suggest that these autoantibodies could be biomarkers to those CFS patients most likely to respond to Rituximab treatment.
Published Studies[edit | edit source]
- 2018, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease
- 2014, The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
- 2013, In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
- 2012, Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
- 2004, Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry? - Donald Staines
Talks and interviews[edit | edit source]
- 2015, Partnerships to Accelerate Biomarker and Mechanisms Discovery in ME/CFS and Fibromyalgia - Professor Alan Light discusses recent studies hypothesising autoimmune causation)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Open Medicine Foundation (Feb 28, 2018). "OMF-funded research: T cells and molecular immunology". Open Medicine Foundation. Retrieved Jul 11, 2019.
- Sotzny, Franziska; Blanco, Julià; Capelli, Enrica; Castro-Marrero, Jesús; Steiner, Sophie; Murovska, Modra; Scheibenbogen, Carmen (2018), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease", Autoimmunity Reviews, 17 (6): 601-609, doi:10.1016/j.autrev.2018.01.009
- von Mikecz, A.; Konstantinov, K.; Buchwald, D. S.; Gerace, L.; Tan, E. M. (Feb 1997). "High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome". Arthritis and Rheumatism. 40 (2): 295–305. ISSN 0004-3591. PMID 9041942.
- "Overlapping Conditions – American ME and CFS Society". ammes.org. Retrieved Aug 12, 2018.
- "Autoantibodies found in subset of CFS patients | #MEAction". www.meaction.net. Retrieved Aug 12, 2018.
- Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter (Feb 2016). "Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 52: 32–39. doi:10.1016/j.bbi.2015.09.013. ISSN 1090-2139. PMID 26399744.
- Morris, Gerwyn; Berk, Michael; Galecki, Piotr; Maes, Michael (Apr 1, 2014). "The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)". Molecular Neurobiology. 49 (2): 741–756. doi:10.1007/s12035-013-8553-0. ISSN 1559-1182.
- Maes, Michael; Ringel, Karl; Kubera, Marta; Anderson, George; Morris, Gerwyn; Galecki, Piotr; Geffard, Michel (Sep 5, 2013). "In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation". Journal of Affective Disorders. 150 (2): 223–230. doi:10.1016/j.jad.2013.03.029. ISSN 0165-0327.
- Maes, Michael; Ringel, Karl; Kubera, Marta; Berk, Michael; Rybakowski, Janusz Rybakowski (Feb 1, 2012). "Increased autoimmune activity against 5-HT : a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression". Journal of affective disorders. 136 (3): 386–392. doi:10.1016/j.jad.2011.11.016. ISSN 0165-0327.
- Staines, Donald R (May 1, 2004). "Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?". Medical Hypotheses. 62 (5): 646–652. doi:10.1016/j.mehy.2004.01.012. ISSN 0306-9877.