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Microbiome hypothesis

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Theory[edit | edit source]

Evidence[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ Navaneetharaja, Navena; Griffiths, Verity; Wileman, Tom; Carding, Simon R. (2016), "A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?", Journal of Clinical Medicine, 5 (6): 55, doi:10.3390/jcm5060055
  2. ↑ Newberry, F.; Hsieh, S.-Y.; Wileman, T.; Carding, S.R. (2018), "Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?", Clinical Science, 132 (5): 523–542, doi:10.1042/CS20171330
  3. ↑ Proal, Amy; Marshall, Trevor (November 2018). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the era of the human microbiome: persistent pathogens drive chronic symptoms by interfering with host metabolism, gene expression and immunity". Frontiers in Pediatrics. doi:10.3389/fped.2018.00373.

virome The human virome is the collection of all viruses that are found in or on humans.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The human virome is the collection of all viruses that are found in or on humans.[1]

virome The human virome is the collection of all viruses that are found in or on humans.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

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