Bupropion is an antidepressant medication sold under the brand names Wellbutrin, Aplenzin, and Zyban, and formerly Budeprion. In addition to treating depression, it is also used to treat seasonal affective disorder (SAD). As a norepinephrine-dopamine reuptake inhibitor (NDRI), it has a modest energizing effect and therefore may be useful for symptom management in ME patients. However, like all antidepressants, it does not address the underlying mechanisms of ME, so it must be used with caution. It should be used only to improve quality of life of an ME patient, rather than to increase functionality.
ME patients may tolerate brand name bupropion better than generic versions due to sensitivities.
References[edit | edit source]
- "Bupropion: MedlinePlus Drug Information". medlineplus.gov. Retrieved Jan 8, 2019.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.