Martin Pall

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Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.[1] He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.[2]

Dr. Pall was one of the authors of the 2011 case definition, the International Consensus Criteria.[3]

Education[edit | edit source]

  • 1962 - B.A., Johns Hopkins University, Baltimore, MD
  • 1968 - Ph.D., California Institute of Technology, Pasadena, CA

NO/ONOO-cycle[edit | edit source]

Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.[4]

He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle.[5] He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.[6]

Book[edit | edit source]

Articles[edit | edit source]

Talks and interviews[edit | edit source]

Publications on ME/CFS[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Faculty". washington.edu. Retrieved Mar 2, 2020. 
  2. ProHealth (Jul 9, 2007). "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol". Prohealth. Retrieved Mar 2, 2020. 
  3. Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (Aug 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890Freely accessible. PMID 21777306. 
  4. "Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained' Illnesses? - Q&A with Martin L. Pall, PhD". Prohealth. Jun 22, 2007. Retrieved Mar 2, 2020. 
  5. Pall, Martin L. (Jun 12, 2007). "Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD". Prohealth. Retrieved Mar 2, 2020. 
  6. 6.06.1 "Invest in ME Research - IIMEC2". www.investinme.org. Retrieved Mar 2, 2020. 
  7. Pall, Martin L. (2007). Explaining "unexplained illnesses" : disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia, post-traumatic stress disorder, Gulf War syndrome, and others. New York: Harrington Park Press. ISBN 978-0-7890-2388-9. OCLC 73993843. 
  8. Pall, M.L. (Jan 2000). "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome". Medical Hypotheses. 54 (1): 115–125. doi:10.1054/mehy.1998.0825. 
  9. Pall, Martin L. (Jan 2000). "Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation". Journal of Chronic Fatigue Syndrome. 7 (4): 45–58. doi:10.1300/J092v07n04_05. ISSN 1057-3321. 
  10. Pall, Martin L. (Jan 2000). "Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger". Journal of Chronic Fatigue Syndrome. 8 (2): 39–44. doi:10.1300/J092v08n02_04. ISSN 1057-3321. 
  11. Pall, M. L. (Aug 2001). "Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite". Medical Hypotheses. 57 (2): 139–145. doi:10.1054/mehy.2001.1325. ISSN 0306-9877. PMID 11461161. 
  12. Pall, M. L.; Satterlee, J. D. (Mar 2001). "Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder". Annals of the New York Academy of Sciences. 933: 323–329. doi:10.1111/j.1749-6632.2001.tb05836.x. ISSN 0077-8923. PMID 12000033. 
  13. Pall, Martin L. (Jan 2002). "Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients". Journal of Chronic Fatigue Syndrome. 10 (3-4): 37–41. doi:10.1300/J092v10n03_04. ISSN 1057-3321. 
  14. Pall, Martin L. (Sep 2002). "Chronic fatigue syndrome/myalgic encephalitis". The British Journal of General Practice: The Journal of the Royal College of General Practitioners. 52 (482): 762; author reply 763–764. ISSN 0960-1643. PMC 1314420Freely accessible. PMID 12236283. 
  15. Smirnova, Iva V.; Pall, Martin (2003). "Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients". Molecular and Cellular Biochemistry. 248 (1/2): 93–95. doi:10.1023/A:1024176016962. 
  16. Pall, Martin L. (Jan 2005). "Nitric oxide and the etiology of chronic fatigue syndrome: Giving credit where credit is due". Medical Hypotheses. 65 (3): 631–633. doi:10.1016/j.mehy.2005.03.026. 
  17. Pall, Martin L. (Oct 2008). "Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease". Medical Hypotheses. 71 (4): 537–541. doi:10.1016/j.mehy.2008.05.023. ISSN 0306-9877. PMID 18667279. 
  18. Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (Aug 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890Freely accessible. PMID 21777306. 
  19. Hoeck, Anna Dorothea; Pall, Martin L. (Feb 2011). "Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?". Medical Hypotheses. 76 (2): 208–213. doi:10.1016/j.mehy.2010.09.032. 

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

serum - The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.