John Chia

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Source: MECFS Alert

Dr. John K. S. Chia is an infectious disease doctor with a medical practice in Torrance, California. Dr. Chia became heavily involved in research and clinical care of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) patients after his son, Andrew Chia, became ill with CFS in 1997. He has published several papers[1] on infectious causes of ME and CFS, including evidence of involvement of enteroviruses such as coxsackie B and echovirus, other viruses such as parvovirus B19, as well as bacteria such as Chlamydia pneumoniae. In addition to his clinical work, he runs his own enterovirus research laboratory[2] and is on the board of directors of the Enterovirus Foundation.

Dr. Chia has performed clinical trials[3] in an attempt to find treatment for patients with ME and CFS. His treatment attempts have focused on the use of antiviral compounds such as amantadine, ribavirin, and lamivudine in addition to immune modulators such as interferon and the plant compound oxymatrine. Towards this end, he and his son, a pharmacist, have developed his own proprietary herbal preparation containing oxymatrine and other plant compounds, called Equilibrant.

International Consensus Criteria[edit | edit source]

Dr. Chia co-authored the 2011 case definition, International Consensus Criteria.[4]

Open Letter to The Lancet[edit | edit source]

Three open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Chia, along with 41 colleagues in the ME/CFS field, signed the second letter. In 2018, Dr. Chia was joined with over 100 signatories.

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Media coverage[edit | edit source]

Publications[edit | edit source]

  • 2003, Correspondence in Clinical Infectious Diseases - "Diverse Etiologies for Chronic Fatigue Syndrome"[14]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  2. EVMED Research
  3. Ribavirin and Interferon-a for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation
  4. Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
  5. Tuller, David (February 10, 2016). "An open letter to The Lancet, again". Virology blog.
  6. Tuller, David (June 19, 2018). "Trial By Error: An Open Letter to The Lancet, Two Years On". Virology blog.
  7. Chia, John K; Chia, Andrew (2004). "Ribavirin and Interferon-α for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation" (PDF). The Journal of Applied Research. 4 (2): 286–292.
  8. Chia, JKS (2005). "The role of enterovirus in chronic fatigue syndrome". J Clin Pathol. 58 (11): 1126–32. doi:10.1136/jcp.2004.020255. PMID 16254097.
  9. Chia, John; Chia, Andrew (2008). "Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach". Journal of Clinical Pathology. 61 (1): 43–48.
  10. Kerr, J.R.; Gough, J.; Richards, S.C.M.; Main, J.; Enlander, D.; McCreary, M.; Komaroff, A.L.; Chia, J.K. (April 1, 2010). "Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis". Journal of General Virology. 91 (4): 893–897. doi:10.1099/vir.0.017590-0. ISSN 0022-1317.
  11. "Dr Chia's ME/CFS post-mortem brain study: Chronic Enterovirus Infection in a Patient With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) – Clinical, Virologic and Pathological Analysis. John Chia, David Wang, Andrew Chia, Rabiha El-Habbal, 2015. Presented at the 19th International Picornavirus Meeting, 2016".
  12. Chia, John K.; Chia, Andrew Y.; Wang, David; El-Habbal, Rabiha (2015), "Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses", Open Journal of Gastroenterology, 5 (4): 21-27., doi:10.4236/ojgas.2015.54005
  13. Germain, Arnaud; Giloteaux, Ludovic; Moore, Geoffrey E.; Levine, Susan M.; Chia, John K.; Keller, Betsy A.; Stevens, Jared; Franconi, Carl J.; Mao, Xiangling; Shungu, Dikoma C.; Grimson, Andrew (March 31, 2022). "Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". JCI Insight. doi:10.1172/jci.insight.157621. ISSN 0021-9738.
  14. Chia, John K.S.; Chia, Andrew (2003), "Diverse Etiologies for Chronic Fatigue Syndrome", Clinical Infectious Diseases, 36 (5): 671-672, doi:10.1086/367666