Hippocampus

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The hippocampus is a region of the brain important for consolidation of information from short-term memory to long-term memory, spatial navigation, and mood. Its name derives from the Greek word for seahorse, in that it mimics a seahorse in size and shape.[1]

A TED talk by Sandrine Thuret reported that the hippocampus was able to generate new nerve cells, a process called neurogenesis, to replace older hippocampus nerves. Brian neurogenesis was once believed to not exist in adults. If the hippocampus can not generate new cells because of illness or medication, poor memory and depression may result. [2]

Hippocampus and Its Role in ME/CFS[edit | edit source]

The hippocampus is shown to be damaged or atrophied in ME/CFS and fibromyalgia. Sleep disturbances common in ME/CFS and FM can, in turn, further impact the hippocampus and initiate a vicious circle of increased disability.[3]

In 2014, researchers in Japan, at the RIKEN Center for Life Science Technologies, in collaboration with Osaka City University and Kansai University of Welfare Sciences, used functional PET imaging to show that levels of inflammation of the nervous system, are higher in patients with chronic fatigue syndrome than in healthy people. The researchers found that inflammation in certain areas of the brain—the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons—was elevated in a way that correlated with the symptoms.[4]

Since the hippocampus is negatively affected by stress, many programs that emphasize stress reduction are used in ME/CFS recovery, such as meditation[5], biofeedback[6], and yoga,[7] to name a few.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. https://en.wikipedia.org/wiki/Hippocampus
  2. https://www.ted.com/talks/sandrine_thuret_you_can_grow_new_brain_cells_here_s_how
  3. http://www.ncbi.nlm.nih.gov/pubmed/26804593 "The role of the hippocampus in the pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)," JM Saury, Medical hypotheses,Med Hypotheses. 2016 Jan;86:30-8. doi: 10.1016/j.mehy.2015.11.024. Epub 2015 Nov 27
  4. http://www.riken.jp/en/pr/press/2014/20140404_1/ “Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a 11C-(R)-PK11195 positron emission tomography study,” The Journal of Nuclear Medicine, vol.55, No.6, 2014, DOI: 10.2967/jnumed.113.131045
  5. http://phoenixrising.me/treating-cfs-chronic-fatigue-syndrome-me/living-ii-mindfulness/meditation/treating-chronic-fatigue-syndrome-mecfs-meditation
  6. http://www.ncbi.nlm.nih.gov/pubmed/8879459 "EEG biofeedback as a treatment for chronic fatigue syndrome: a controlled case report," Behavior Medicine,1996 Summer;22(2):77-81
  7. http://www.yogajournal.com/article/health/rest-for-the-weary/

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.