Hypokalemic periodic paralysis
Hypokalemic periodic paralysis (hypoKPP) is a rare channelopathy characterized by repeated, temporary attacks of muscle weakness or paralysis that are the result of a fall in potassium levels in the blood.
Hypokalemic periodic paralysis can be either genetic (familial) or acquired (not life long), and is classed as a form of acute flaccid paralysis, and has been described in people with severe myalgic encephalomyelitis.
Types of periodic paralysis[edit | edit source]
Hypokalemic periodic paralysis is one of several types of periodic paralysis.
Muscle weakness[edit | edit source]
Weakness may be mild and limited to certain muscle groups, resulting in partial paralysis or paresis, or more severe full-body paralysis. During an attack reflexes may be decreased or absent. Hypokalemic periodic paralysis attacks may last for a few hours, or persist for several days. Recovery is usually sudden, and occurs when the swollen muscles release potassium as they recover.
Prevalence[edit | edit source]
Hypokalemic periodic paralysis is to be rare in the general population, but has been found in people with ME/CFS, especially in people with severe and very severe ME.
Symptom Recognition[edit | edit source]
Hypokalemic periodic paralysis was only discovered fairly recently.
Notable studies[edit | edit source]
Causes of temporary paralysis[edit | edit source]
In individuals with the inherited genetic mutation, attacks often begin in adolescence. Attacks of paralysis are most commonly occur:
- on awakening or after sleep
- after rest following strenuous exercise (attacks during exercise are rare)
- after high carbohydrate meals
- after meals with high sodium content (high salt content)
- as a result of sudden changes in temperature, or cold temperatures
- sensory input, such as noise, or flashing lights cause trigger paralysis
- and even excitement.
Potential Treatments[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
Channelopathies (review) - Kim June-Bum.
References[edit | edit source]
- Kim, June-Bum (Jan 2014). "Channelopathies". Korean Journal of Pediatrics. 57 (1): 1–18. doi:10.3345/kjp.2014.57.1.1. ISSN 1738-1061. PMC . PMID 24578711.
- Padmaperuma, Pacd; Dissanayake, H. A. (Jul 18, 2018). "Periodic paralysis: what clinician needs to know?". Endocrinology & Metabolism International Journal. 6 (4): 1–0. doi:10.15406/emij.2018.6.00189. ISSN 2473-0815.
- Crowhurst, Greg; Crowhurst, Linda (Aug 8, 2013). "Paralysis, a qualitative study of people with Severe Myalgic Encephalomyelitis". Stonebird. Retrieved Dec 28, 2018.
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6