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Medicine sensitivities or drug intolerance/sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects. It is not to be confused with a drug allergy, which is a form of drug intolerance, but requires an immune-mediated component. It is also not to be confused with drug tolerance ("drug resistance," or tachyphylaxis) which refers to a lack of adverse effects even at higher than average doses. Some instances of drug intolerance are known to result from genetic variations in drug metabolism.
It is a common problem for ME/CFS patients.
Symptom recognition[edit | edit source]
- The International Consensus Criteria lists sensitivities to food, medications, odors or chemicals as an optional criteria for diagnosis, under the section C. Immune, gastro-intestinal and genitourinary Impairments.
- 2018, The Centers for Disease Control and Prevention (CDC) website ME/CFS page Monitoring the Use of All Medicines and Supplements gives guidance for healthcare providers on medications for ME/CFS patients.
Many patients with ME/CFS are sensitive to medications. This is particularly true of any medication that acts on the central nervous system, such as sedating medications: therapeutic benefits can often be achieved at lower-than-standard doses. Patients with ME/CFS might tolerate or need only a fraction of the usual recommended doses for medications. After initial management with lower dosing, one or more gradual increases may be considered as necessary and as tolerated by the patient.
Prevalence[edit | edit source]
- In a 2001 Belgian study, 48.5% of patients meeting the Fukuda criteria and 54.8% of patients meeting the Holmes criteria, in a cohort of 2073 CFS patients, reported new sensitivities to food or drugs.
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- "Drug intolerance". Wikipedia. Mar 12, 2018.
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, DP; Light, AR; Marshall-Gradisnik, S; Mena, I; Mikovits, JA; Miwa, K; Murovska, M; Pall, ML; Stevens, SR (Aug 22, 2011), "Myalgic encephalomyelitis: International Consensus Criteria", Journal of Internal Medicine, 270 (4): 327–338, doi:10.1111/j.1365-2796.2011.02428.x, PMID 21777306
- "Monitoring the Use of All Medicines and Supplements | Clinical Care of Patients | Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC". www.cdc.gov. Jul 10, 2018. Retrieved Aug 23, 2018.
- De Becker, Pascale; McGregor, Neil; De Meirleir, Kenny (December 2001). "A definition‐based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome". Journal of Internal Medicine. 250 (3): 234–240. doi:10.1046/j.1365-2796.2001.00890.x.
Myalgic encephalomyelitis or chronic fatigue syndrome, often used when both illnesses are considered the same.