Vaccine

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A vaccine is a biological preparation that provides active acquired immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic (example: to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (e.g., vaccines against cancer are being investigated).[1][2][3][4][5]

Risk in developing ME/CFS

According to the 2018 version of The Clinician’s Vaccine Safety Resource Guide Vaccines: "Vaccines currently routinely recommended to the general population in the U.S. have not been shown to cause fibromyalgia or chronic fatigue syndrome (CFS)."[6]

A 2015 complete population study of data from 2009 to 2012 in Norway, following the country's mass vaccination during the 2009 influenza A (H1N1) pandemic, found that vaccination produced no increased risk of CFS/ME. By contrast, infection with influenza more than doubled the risk of developing CFS/ME.[7]

Some have reported developing ME/CFS after receiving vaccinations for foreign travel but a causal relationship has not been shown.[8]

In one case of a 43-year-old man who developed CFS after having five vaccinations, with no previous ill health, Dr. Chris Exley and team at the Birchall Centre at Keele University in Staffordshire, UK, in 2008 "proposed that the cause of the CFS in this individual was a heightened immune response, initially to the aluminium in each of the adjuvants and thereafter spreading to other significant body stores of aluminium."[9] However, under this hypothesis, Dr. Exley anticipated that the mass human papillomavirus (HPV) vaccination program then recently begun in the UK would carry related risks, as that vaccine also uses aluminium-based adjuvant. That was not borne out: a 2013 study concluded there is no evidence the HPV vaccine leads to developing chronic fatigue syndrome.[10]

Risk in developing Gulf War Illness

Vaccinations have been proposed as an etiological factor in Gulf War Illness, especially the mass vaccinations given prior to military deployment.[11]

Vaccination in the presence of elevated cortisol levels can drive cytokine expression toward Th2 dominance.[12][13]

Influenza vaccine for ME/CFS and Fibromyalgia patients

Publications

  • 2018, Do Vaccines Cause Fibromyalgia or Chronic Fatigue Syndrome (CFS)? in The Clinician’s Vaccine Safety Resource Guide[6]

See also

Learn more

References

  1. Melief C, van Hall T, Arens R, Ossendorp F, van der Burg S (2015). "Therapeutic cancer vaccines". J Clin Invest. 125 (9): 3401–12. doi:10.1172/JCI80009. Archived from the original on Jun 29, 2017. 
  2. Bol K, et al. (2016). "Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity". Cancer Immunology, Immunotherapy. 65 (3): 327–39. doi:10.1007/s00262-016-1796-7. 
  3. Brotherton J (2015). "HPV prophylactic vaccines: lessons learned from 10 years experience". Future Medicine. 10 (8): 999–1009. doi:10.2217/fvl.15.60. 
  4. Frazier I (2014). "Development and Implementation of Papillomavirus Prophylactic Vaccines". J. Immunol. 192 (9): 4007–11. doi:10.4049/jimmunol.1490012. Archived from the original on Aug 11, 2017. 
  5. "Vaccine". Wikipedia. Aug 15, 2018. 
  6. 6.06.1 Dudley, Matthew Z.; Salmon, Daniel A.; Halsey, Neal A.; Orenstein, Walter A.; Limaye, Rupali J.; O’Leary, Sean T.; Omer, Saad B. (2018). "Do Vaccines Cause Fibromyalgia or Chronic Fatigue Syndrome (CFS)?". Cham: Springer International Publishing: 241–244. doi:10.1007/978-3-319-94694-8_35. ISBN 9783319946931. 
  7. Magnus, Per; Gunnes, Nina; Tveito, Kari; Bakken, Inger Johanne; Ghaderi, Sara; Stoltenberg, Camilla; Hornig, Mady; Lipkin, W. Ian; Trogstad, Lill (Nov 17, 2015). "Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine". Vaccine. 33 (46): 6173–6177. doi:10.1016/j.vaccine.2015.10.018. ISSN 1873-2518. PMID 26475444. 
  8. "Chronic Fatigue Syndrome Subgroups - different triggers for this chronic illness". HealingCFSME.com. Retrieved Aug 24, 2018. 
  9. "Vaccine-Related Chronic Fatigue Syndrome In An Individual Demonstrating Aluminium Overload". ScienceDaily. Keele University. Nov 18, 2008. Retrieved Aug 24, 2018 – via Science Daily. 
  10. "Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK". Vaccine. 31 (43): 4961–4967. Oct 9, 2013. doi:10.1016/j.vaccine.2013.08.024. ISSN 0264-410X. 
  11. Peakman, Mark; Skowera, Ania; Hotopf, Matthew (2006), "Immunological dysfunction, vaccination and Gulf War illness", Immunological dysfunction, vaccination and Gulf War illness. Philosophical Transactions of the Royal Society B: Biological Sciences, 361 (1468): 681–687, doi:10.1098/rstb.2006.1826 
  12. Bernton, E.; Hoover, D.; Galloway, R.; Popp, K. (Dec 29, 1995). "Adaptation to chronic stress in military trainees. Adrenal androgens, testosterone, glucocorticoids, IGF-1, and immune function". Annals of the New York Academy of Sciences. 774: 217–231. ISSN 0077-8923. PMID 8597461. 
  13. Ramírez, F.; Fowell, D. J.; Puklavec, M.; Simmonds, S.; Mason, D. (Apr 1, 1996). "Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro". Journal of Immunology (Baltimore, Md.: 1950). 156 (7): 2406–2412. ISSN 0022-1767. PMID 8786298. 
  14. "5 Vaccine Delivery Methods of the Future". Vaccine Nation. Retrieved Aug 25, 2018. 
  15. Mandal, Ananya (Jan 9, 2010). "Vaccine Delivery". News-Medical.net. Retrieved Aug 25, 2018. 
  16. "Vaccine Storage and Handling" (PDF). cdc.gov. Centers for Disease Control and Prevention. 
  17. "Vaccines". blausen.com. Retrieved Aug 25, 2018. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.